This chapter is dedicated to the analysis and the interpretation of graphical documents, and as such, builds upon many of the topics covered in other parts of this handbook. It will therefore not focus on any of the technical issues related to graphical documents, such as low level filtering and binarization, primitive extraction and vectorization as developed in Chapters 2.1 and 5.1 or symbol recognition, for instance, as developed in Chapter 5.2. These tools are put in a broader framework and threaded together in complex pipelines to solve interpretation questions. This chapter provides an overview of how analysis strategies have contributed to constructing these pipelines, how specific domain knowledge is integrated in these analyses, and which interpretation contexts have been contributed to successful approaches.