Structural Health Monitoring is a growing area of interest given the benefits obtained from its use. This area includes different tasks in the damage identification process, the main important, is the damage detection since an early detection allows to avoid possible catastrophes in structures in service. Practical solutions require a big quantity of sensors and a robust system to process and obtain a reliable solution. In this sense, bio-inspired algorithms provide tools for an effective data analysis taking advantage of the developments provided by the nature by means of computational algorithms. As a contribution in this area, this paper presents a methodology for structural damage detection using a type of artificial intelligence that is called artificial immune system. The developed methodology includes the inspection of the structure by means of a distributed piezoelectric active sensor network at different actuation phases to define a baseline by each actuation phase using data from the structure when it is known as healthy. In a second step, same experiments are performed to the structure when its structural state is unknown to determine the presence of damage by using the developed artificial immune system. Results show that the proposed methodology allows to detect damages in the experimental setup.