HAL - INRIA :: [inria-00145537, version 2] Checking Consistency Between Expression Data and Large Scale Regulatory Networks: A Case Study

inria-00145537, version 2

Checking Consistency Between Expression Data and Large Scale Regulatory Networks: A Case Study

Carito Guziolowski ()^a^, 1, Philippe Veber^a^, 1, Michel Le Borgne ()^b^, 1, Ovidiu Radulescu ()^b^, 1, Anne Siegel ( Author to contact preferably )^c^, 1

N° RR-6190 (2007)

Abstract: We proposed in previous articles a qualitative approach to check the compatibility between a model of interactions and gene expression data. The purpose of the present work is to validate this methodology on a real-size setting. We study the response of Escherichia coli regulatory network to nutritional stress, and compare it to publicly available DNA microarray experiments. We show how the incompatibilities we found reveal missing interactions in the network, as well as observations in contradiction with available literature.

a – INRIA
b – Université Rennes I
c – CNRS
1: SYMBIOSE (INRIA - IRISA)
CNRS : UMR6074 – INRIA – INSA Rennes – Université de Rennes 1

inria-00145537, version 2
http://hal.inria.fr/inria-00145537
oai:hal.inria.fr:inria-00145537
From: Rapport De Recherche Inria <>
Submitted on: Tuesday, 15 May 2007 09:41:25
Updated on: Tuesday, 6 October 2009 10:47:42

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