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inria-00178914, version 1

Checking Consistency Between Expression Data and Large Scale Regulatory Networks: A Case Study

Carito Guziolowski ( Author to contact preferably ) ¹, Philippe Veber^a^, 1, Michel Le Borgne ()^b^, 1, Ovidiu Radulescu ()^b^, 1, 2, Anne Siegel ()^c^, 1

The Journal of Biological Physics and Chemistry 7 (2007) 37-43

Abstract: We proposed in previous articles a qualitative approach to check the compatibility between a model of interactions and gene expression data. The purpose of the present work is to validate this methodology on a real-size setting. We study the response of E.coli regulatory network to nutritional stress, and compare it to publicly available DNA microarray experiments. We show how the incompatibilities we found reveal missing interactions in the network, as well as observations in contradiction with available literature.

a – INRIA
b – Université Rennes I
c – CNRS
1: SYMBIOSE (INRIA - IRISA)
CNRS : UMR6074 – INRIA – INSA Rennes – Université de Rennes 1
2: Institut de Recherche Mathématique de Rennes (IRMAR)
CNRS : UMR6625 – Université de Rennes 1 – École normale supérieure de Cachan - ENS Cachan – INSA Rennes – Université Rennes II

inria-00178914, version 1
http://hal.inria.fr/inria-00178914
oai:hal.inria.fr:inria-00178914
From: Anne Siegel <>
Submitted on: Friday, 12 October 2007 17:10:25
Updated on: Wednesday, 24 March 2010 09:37:53

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