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inria-00181450, version 1

Dynamical robustness of biological networks with hierarchical distribution of time scales

Alexander N. Gorban a1, Ovidiu Radulescu (Author to contact preferably) b23

IET Systems Biology (2007) nc

Abstract: We analyze the concepts of distributed robustness and r-robustness proposed by biologists to explain a variety of stability phenomena in molecular biology. Then we discuss the robustness of the relaxation time using a chemical reaction description of genetic and signalling networks. First, we obtain the following result for linear networks: for large multiscale systems with hierarchical distribution of time scales the variance of the inverse relaxation time (as well as the variance of the stationary rate) is much lower than the variance of the separate constants. Moreover, it can tend to 0 faster than 1/n, where n is the number of reactions. We argue that similar phenomena are valid in the nonlinear case as well. As a numerical illustration we use a model of signalling network for the important transcription factor NFkB

  • Domain : Computer Science/Bioinformatics
    Life Sciences/Quantitative Methods
    Mathematics/Dynamical Systems
 
  • inria-00181450, version 1
  • oai:hal.inria.fr:inria-00181450
  • From: 
  • Submitted on: Tuesday, 23 October 2007 18:55:34
  • Updated on: Wednesday, 24 March 2010 09:36:38
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