Abstract: In this report we propose a solution to the direct problem of VSD optical imaging based on a neural field model of a cortical area and reproduce optical signals observed in various mammals cortices. We first present a biophysical approach to neural fields and show that these easily integrate the biological knowledge on cortical structure, especially horizontal and vertical connectivity patterns. After having introduced the reader to VSD optical imaging, we propose a biophysical formula expressing the optical imaging signal in terms of the activity of the field. Then, we simulate optical signals that have been observed by experimentalists. We have chosen two experimental sets: the line-motion illusion in the visual cortex of mammals (jancke, chavane, et al. 2004} and the spread of activity in the rat barrel cortex (petersen, grinvald, et al. 2003). We begin with a structural description of both areas, with a focus on horizontal connectivity. Finally we simulate the corresponding neural field equations and extract the optical signal using the direct problem formula developed in the preceding sections. We have been able to reproduce the main experimental results with these models.