inria-00201086, version 1
Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling
Résumé : Auto/paracrine cell-to-cell communications via diffusive messengers can be coupled to a positive feedback loop in which cell stimulation by a messenger results in the production of new messengers. This yields a potential mechanism for relay transmission of the emitted message. This paper investigates the influence of noise on this mutual coupling of the cells with their environment, using numerical simulations of a stochastic minimal model. The results demonstrate that the deterministic (mean-field) approximation of this stochastic process fails short of predicting its behaviour because of the presence of strong noise-induced fluctuations. Instead, the behaviour of the model can be explained by the occurrence of a nonequilibrium phase transition, which is found to be in the universality class of directed percolation. This provides a theoretical framework to understand signal transmission in these stochastic systems.
- 1 : ALCHEMY (INRIA Futurs)
- INRIA – CNRS : UMR8623 – Université Paris XI - Paris Sud
- Domaine : Informatique/Bio-informatique
Sciences du Vivant/Bio-Informatique, Biologie Systémique
Informatique/Modélisation et simulation
Physique/Matière Condensée/Systèmes désordonnés et réseaux de neurones
Physique/Physique/Biophysique
Sciences du Vivant/Biologie cellulaire/Interactions cellulaires
- inria-00201086, version 1
- http://hal.inria.fr/inria-00201086
- oai:hal.inria.fr:inria-00201086
- Contributeur : Hugues Berry
- Soumis le : Dimanche 23 Décembre 2007, 12:09:56
- Dernière modification le : Dimanche 23 Décembre 2007, 15:17:57







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