inria-00408293, version 1
Spatiotemporal Atlas Estimation for Developmental Delay Detection in Longitudinal Datasets
Stanley Durrleman
1, 2Xavier Pennec
1Guido Gerig a, 3Alain Trouvé
2Nicholas Ayache
1
N° RR-6952 (2009)
Résumé : We propose a new methodology to analyze the anatomical variability of a set of longitudinal data (population scanned at several ages). This method accounts not only for the usual 3D anatomical variability (geometry of structures), but also for possible changes in the dynamics of evolution of the structures. It does not require that subjects are scanned the same number of times or at the same ages. First a regression model infers a continuous evolution of shapes from a set of observations of the same subject. Second, spatiotemporal registrations deform jointly (1) the geometry of the evolving structure via 3D deformations and (2) the dynamics of evolution via time change functions. Third, we infer from a set of subjects a prototype scenario of evolution and its 4D variability within the population. Our method is used to analyze the morphological evolution of 2D profiles of hominids skulls and to analyze brain growth from amygdala of autistics, developmental delay and control children.
- a – University of Utah
- 1 : ASCLEPIOS (INRIA Sophia Antipolis)
- INRIA
- 2 : Centre de Mathématiques et de Leurs Applications (CMLA)
- CNRS : UMR8536 – École normale supérieure de Cachan - ENS Cachan
- 3 : Scientific Computing and Imaging Institute (SCI Institute)
- University of Utah
- Domaine : Informatique/Traitement du signal et de l'image
Sciences de l'ingénieur/Traitement du signal et de l'image - Mots-clés : Computational Anatomy – longitudinal data – spatiotemporal variability – 4D registration – time regression – atlas construction – large deformation – diffeomorphism – currents
- Référence interne : RR-6952
- inria-00408293, version 1
- http://hal.inria.fr/inria-00408293
- oai:hal.inria.fr:inria-00408293
- Contributeur : Stanley Durrleman
- Soumis le : Jeudi 30 Juillet 2009, 10:47:47
- Dernière modification le : Mercredi 9 Septembre 2009, 11:12:26






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