inria-00517994, version 1
Atlas-Based Reduced Models of Blood Flows for Fast Patient-Specific Simulations
Kristin Mcleod a, 1Alfonso Caiazzo
2Miguel Angel Fernandez 2Tommaso Mansi
1Irene Vignon-Clementel
2Maxime Sermesant
1Xavier Pennec
a, 1Younes Boudjemline b, 3Jean-Frédéric Gerbeau
2
STACOM 6364 (2010) 95-104
Abstract: Model-based interpretation of the complex clinical data now available (shape, motion, flow) can provide quantitative information for diagnosis as well as predictions. However such models can be extremely time consuming, which does not always fit with the clinical time constraints. The aim of this work is to propose a model reduction technique to perform faster patient-specific simulations with prior knowledge built from simulations on an average anatomy. Rather than simulating a full fluid problem on individual patients, we create a representative `template' of the artery shape. A full flow simulation is carried out only on this template, and a reduced model is built from the results. Then this reduced model can be transported to the individual geometries, allowing faster computational analysis. % Here we propose a preliminary validation of this idea. A well-posed framework based on currents representation of shapes is used to create an unbiased template of the pulmonary artery for 4 patients with Tetralogy of Fallot. Then, a reduced computational fluid dynamics model is built on this template. Finally, we demonstrate that this reduced model can represent a specific patient simulation.
- a – INRIA
- b – Hôpital Necker - Enfants Malades
- 1: ASCLEPIOS (INRIA Sophia Antipolis)
- INRIA
- 2: REO (INRIA Rocquencourt)
- INRIA – Laboratoire Jacques-Louis Lions
- 3: Service de cardiologie pédiatrique
- Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Necker - Enfants Malades – Université Paris V - Paris Descartes
- Domain : Mathematics/Numerical Analysis
Life Sciences/Bioengineering - Comment : The original publication is available at www.springerlink.com.
- inria-00517994, version 1
- http://hal.inria.fr/inria-00517994
- oai:hal.inria.fr:inria-00517994
- From: Jean-Frédéric Gerbeau
- Submitted on: Thursday, 16 September 2010 10:39:14
- Updated on: Friday, 19 November 2010 11:40:02






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