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inria-00517994, version 1

Atlas-Based Reduced Models of Blood Flows for Fast Patient-Specific Simulations

Kristin Mcleod a1, Alfonso Caiazzo () 2, Miguel Angel Fernandez 2, Tommaso Mansi () 1, Irene Vignon-Clementel () 2, Maxime Sermesant () 1, Xavier Pennec () a1, Younes Boudjemline b3, Jean-Frédéric Gerbeau (Author to contact preferably) 2

STACOM 6364 (2010) 95-104

Abstract: Model-based interpretation of the complex clinical data now available (shape, motion, flow) can provide quantitative information for diagnosis as well as predictions. However such models can be extremely time consuming, which does not always fit with the clinical time constraints. The aim of this work is to propose a model reduction technique to perform faster patient-specific simulations with prior knowledge built from simulations on an average anatomy. Rather than simulating a full fluid problem on individual patients, we create a representative `template' of the artery shape. A full flow simulation is carried out only on this template, and a reduced model is built from the results. Then this reduced model can be transported to the individual geometries, allowing faster computational analysis. % Here we propose a preliminary validation of this idea. A well-posed framework based on currents representation of shapes is used to create an unbiased template of the pulmonary artery for 4 patients with Tetralogy of Fallot. Then, a reduced computational fluid dynamics model is built on this template. Finally, we demonstrate that this reduced model can represent a specific patient simulation.

  • Domain : Mathematics/Numerical Analysis
    Life Sciences/Bioengineering
  • Comment : The original publication is available at www.springerlink.com.
 
  • inria-00517994, version 1
  • oai:hal.inria.fr:inria-00517994
  • From: 
  • Submitted on: Thursday, 16 September 2010 10:39:14
  • Updated on: Friday, 19 November 2010 11:40:02
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