Parameter Estimation of a 3D Cardiac Electrophysiology Model Including the Restitution Curve Using Optical and MR Data - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Communication Dans Un Congrès Année : 2009

Parameter Estimation of a 3D Cardiac Electrophysiology Model Including the Restitution Curve Using Optical and MR Data

Résumé

Personalisation of a cardiac electrophysiology model is crucial not only to understand and simulate the actual dynamics of pathologies such as arrhythmia, but also to predict the behaviour of the heart in a therapeutic environment. In this paper, we present personalisation of a simplified ionic 3D cardiac electrophysiology model, the MitchellSchaeffer model (2003), for single and multiple heart rates. The personalisation is performed using the epicardial depolarisation and repolarisation maps obtained ex-vivo from optical imaging of large porcine healthy heart. First, we present a method to personalise the model to a constant heart rate, thus estimating the model parameters that could result in model predictions similar to the actual clinical data at the given heart rate used for personalisation. Next, we show a method to personalise the model to the observed actual spatial dispersion of the action potential duration restitution property in order to have model predictions more similar to the clinical data also at multiple heart rates
Fichier principal
Vignette du fichier
relan_WorldCongress09.pdf (272.29 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inria-00616143 , version 1 (08-07-2013)

Identifiants

Citer

Jatin Relan, Maxime Sermesant, Mihaela Pop, Hervé Delingette, Michel Sorine, et al.. Parameter Estimation of a 3D Cardiac Electrophysiology Model Including the Restitution Curve Using Optical and MR Data. World Congress on Medical Physics and Biomedical Engineering, 2009, Munich, Germany. pp.1716--1719, ⟨10.1007/978-3-642-03882-2_456⟩. ⟨inria-00616143⟩
178 Consultations
154 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More