Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci

Claude Chelala; Marie-Dominique Devignes; Sandrine Imbeaud; Rima Zoorob; David Cox; Charles Auffray; Emmanuel Curis; Simone Benazeth

inria-00000241, version 1

Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci

Claude Chelala ¹, Marie-Dominique Devignes () ², Sandrine Imbeaud ¹, Rima Zoorob ¹, David Cox, Charles Auffray ¹, Emmanuel Curis ³, Simone Benazeth ³

Journal of Biological Systems 10 (2002) 303-317

Résumé : The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only common markers between genetic or RH maps and the sequence map. Local inversions of markers have been detected. Ratios between either genetic or RH distances and sequence-based distances have been calculated for each map interval. Hot zones for recombination or radiation breakage have been delineated by merging together intervals displaying high distance ratios and located close to each other for sequence-constrained RH maps, and for female and male genetic maps. A statistically significant positive correlation was found between the distribution of disease-related genes and the hot zones for recombination or radiation breakage on both female genetic and Stanford-G3 RH maps. This observation indicates that investigation of chromosomal regions displaying inconsistencies between RH or genetic linkage and sequence-based maps can accelerate the initial phase of identification of disease-associated genes.

1 : Genexpress
CNRS : FRE2571
2 : LANGUE ET DIALOGUE (INRIA Lorraine - LORIA)
INRIA – CNRS : UMR7503 – Université Henri Poincaré - Nancy I – Université Nancy II – Institut National Polytechnique de Lorraine (INPL)
3 : Laboratoire de Biomathematique
Université Paris V - Paris Descartes

inria-00000241, version 1
http://hal.inria.fr/inria-00000241
oai:hal.inria.fr:inria-00000241
Contributeur : Marie-Dominique Devignes <>
Soumis le : Vendredi 16 Septembre 2005, 12:40:15
Dernière modification le : Jeudi 6 Octobre 2005, 16:21:56

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DOI : 10.1142/S0218339002000743

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%% inria-00000241, version 1
%% http://hal.inria.fr/inria-00000241
@article{chelala:inria-00000241,
    hal_id = {inria-00000241},
    url = {http://hal.inria.fr/inria-00000241},
    title = {{Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related Loci}},
    author = {Chelala, Claude and Devignes, Marie-Dominique and Imbeaud, Sandrine and Zoorob, Rima and Cox, David and Auffray, Charles and Curis, Emmanuel and Benazeth, Simone},
    abstract = {{The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only common markers between genetic or RH maps and the sequence map. Local inversions of markers have been detected. Ratios between either genetic or RH distances and sequence-based distances have been calculated for each map interval. Hot zones for recombination or radiation breakage have been delineated by merging together intervals displaying high distance ratios and located close to each other for sequence-constrained RH maps, and for female and male genetic maps. A statistically significant positive correlation was found between the distribution of disease-related genes and the hot zones for recombination or radiation breakage on both female genetic and Stanford-G3 RH maps. This observation indicates that investigation of chromosomal regions displaying inconsistencies between RH or genetic linkage and sequence-based maps can accelerate the initial phase of identification of disease-associated genes.}},
    language = {Anglais},
    affiliation = {Genexpress , LANGUE ET DIALOGUE - INRIA Lorraine - LORIA , Laboratoire de Biomathematique},
    publisher = {WorldSciNet},
    pages = {303-317},
    journal = {Journal of Biological Systems},
    volume = {10},
    note = {http://www.worldscinet.com },
    audience = {non sp{\'e}cifi{\'e}e },
    doi = {10.1142/S0218339002000743 },
    year = {2002},
}

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