Anxiety in Mice: A Principal Component Analysis Study

Yan Clément; Chantal Joubert; Caroline Kopp; Eve M. Lepicard; Patrice Venault; René Misslin; Martine Cadot; Georges Chapouthier

inria-00186107, version 1

Anxiety in Mice: A Principal Component Analysis Study

Yan Clément ¹, Chantal Joubert ², Caroline Kopp ³, Eve M. Lepicard ², Patrice Venault ², René Misslin ³, Martine Cadot ()^a^, 4, Georges Chapouthier ²

Neural plasticity (2007)

Abstract: Two principal component analyses of anxiety were undertaken investigating two strains of mice (ABP/Le and C57BL/6ByJ) in two different experiments, both classical tests for assessing anxiety in rodents. The elevated plus-maze and staircase were used for the first experiment, and a free exploratory paradigm and light-dark discrimination were used for the second. The components in the analyses produced definitions of four fundamental behavior patterns: novelty-induced anxiety, general activity, exploratory behavior, and decision making. We also noted that the anxious phenotype was determined by both strain and experimental procedure. The relationship between behavior patterns and the use of specific tests plus links with the genetic background are discussed.

a – Université Henri Poincaré - Nancy I
1: Matrice extracellulaire et régulations cellulaires (MERC)
CNRS : UMR6198 – Université de Reims - Champagne Ardenne
2: Vulnérabilité Adaptation et Psychopathologie (VAP)
CNRS : UMR7593 – Université Pierre et Marie Curie (UPMC) - Paris VI – Université Paris VII - Paris Diderot
3: Laboratoire d'Ethologie et de Neurobiologie, URA CNRS 1295
Université Louis Pasteur - Strasbourg I
4: PAROLE (INRIA Lorraine - LORIA)
INRIA – CNRS : UMR7503 – Université Henri Poincaré - Nancy I – Université Nancy II – Institut National Polytechnique de Lorraine (INPL)

inria-00186107, version 1
http://hal.inria.fr/inria-00186107
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From: Martine Cadot <>
Submitted on: Wednesday, 7 November 2007 22:46:12
Updated on: Wednesday, 22 June 2011 10:20:59

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DOI: 10.1155/2007/35457

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