Abstract: Many algorithms for approximate nearest neighbor search in high-dimensional spaces partition the data into clusters. At query time, for efficiency, an index selects the few (or a single) clusters nearest to the query point. Clusters are often produced by the well-known k-means approach since it has several desirable properties. On the downside, it tends to produce clusters having quite different cardinalities. Imbalanced clusters negatively impact both the variance and the expectation of query response times. This paper proposes to modify k-means centroids to produce clusters with more comparable sizes without sacrificing the desirable properties. Experiments with a large scale collection of image descriptors show that our algorithm significantly reduces the variance of response times without severely impacting the search quality.