hal-00350299, version 1

Rule-based modelling and model perturbations

Vincent Danos ¹, Jérôme Feret ², Walter Fontana ³, Russ Harmer () ¹, Jean Krivine ³

(31/12/2008)

• 1 :  Preuves, Programmes et Systèmes (PPS)
• http://www.pps.jussieu.fr
  CNRS : UMR7126 – Université Paris VII - Paris Diderot Université Denis Diderot 2 Place Jussieu - case 7014 75005 PARIS France
• 2 :  ABSTRACTION (INRIA Rocquencourt)
• http://www.inria.fr/recherche/equipes/abstraction.en.html
  INRIA – Ecole normale supérieure de Paris - ENS Paris – CNRS : UMR 8548 France
• 3 :  Harvard Medical School (HMS)
• http://www.hms.harvard.edu
  Harvard University 25 Shattuck Street Boston, MA 02115 États-Unis

Références bibliographiques

• Type de publication : Documents sans référence de publication (Preprint)
• Domaine :

  Informatique/Bio-informatique

  Sciences du Vivant/Bio-Informatique, Biologie Systémique

  Informatique/Modélisation et simulation

• Titre : Rule-based modelling and model perturbations
• Résumé : Rule-based modelling has already proved successful for taming the combinatorial complexity, typical of cellular signalling, caused by the combination of physical protein-protein interactions and modifications that may generate astronomical numbers of unique molecular species. However, traditional rule-based approaches, based on an unstructured space of agents and rules, remain susceptible to other combinatorial explosions such as those caused by mutated agents, that share most but not all rules with their wild-type counterparts, and drugs, which must be distinguished from physiological ligands. We present here a syntactic extension of Kappa, an established rule-based modelling platform, that enables the expression of a structured space of agents and rules that simultaneously allows us to comfortably express mutated agents, splice variants, families of related proteins and drug interventions. This also enables a mode of model construction where, starting from our current consensus model, we attempt to reproduce \emph{in numero} the mutational and more generally perturbational analyses that were used in the process of inferring those pathways---and in the light of this, we may need to upgrade our consensus model.
• Langue du texte
  intégral : Anglais
• Date de production,
  écriture : 31/12/2008

Liste des fichiers attachés à ce document :

• hal-00350299, version 1
• http://hal.archives-ouvertes.fr/hal-00350299
• oai:hal.archives-ouvertes.fr:hal-00350299
• Contributeur : Russ Harmer <>
• Soumis le : Mardi 6 Janvier 2009, 14:00:34
• Dernière modification le : Mardi 6 Janvier 2009, 14:08:57