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inria-00401772, version 1

Inhibitory control of spike timing precision

Maxime Ambard () 1, Dominique Martinez () 1

Neurocomputing / EEG Neurocomputing 70, 1-3 (2006) 200-205

Résumé : GABAergic inhibition via local interneurons may play a role in enhancing spike timing precision in principal cells, since it tends to eliminate the influence of initial conditions. However, both the number and the timing of inhibitory synaptic events may be variable across repeated trials. How does this variability affect the spike timing precision in principal neurons? In this paper, we derive an analytical expression for the spike output jitter as a function of the variability of the received inhibition. This study predicts that variable inhibition is especially tolerated as the number of inhibitory cells is large and the decay time constant of the GABAergic synapse is small, which is consistent with experimental data from early olfactory systems (antennal lobe for insects, olfactory bulb for vertebrates).

  • 1 :  CORTEX (INRIA Lorraine - LORIA)
  • INRIA – CNRS : UMR7503 – Université Henri Poincaré - Nancy I – Université Nancy II – Institut National Polytechnique de Lorraine (INPL)
  • Domaine : Informatique/Réseau de neurones
  • Mots-clés : Firing precision – GABAergic inhibition – Spiking neurons – Olfaction – Olfactory bulb
 
  • inria-00401772, version 1
  • oai:hal.inria.fr:inria-00401772
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  • Soumis le : Lundi 6 Juillet 2009, 10:13:01
  • Dernière modification le : Jeudi 9 Juillet 2009, 15:46:40