Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.

Rachel Linger; Darshna Dudakia; Robert Huddart; Kathy Tucker; Michael Friedlander; Kelly-Anne Phillips; David Hogg; Michael A S Jewett; Radka Lohynska; Gedske Daugaard; Stéphane Richard; Agnes Chompret; Dominique Stoppa-Lyonnet; Catherine Bonaïti-Pellié; Axel Heidenreich; Peter Albers; Edith Olah; Lajos Geczi; Istvan Bodrogi; Peter A Daly; Parry Guilford; Sophie D Fosså; Ketil Heimdal; Sergei A Tjulandin; Ludmila Liubchenko; Hans Stoll; Walter Weber; Lawrence Einhorn; Mary McMaster; Larissa Korde; Mark H Greene; Katherine L Nathanson; Victoria Cortessis; Douglas F Easton; D Timothy Bishop; Michael R Stratton; Elizabeth A Rapley

hal-00281481, version 1

Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.

Rachel Linger ¹, Darshna Dudakia ¹, Robert Huddart ², Kathy Tucker ³, Michael Friedlander ³, Kelly-Anne Phillips ⁴, David Hogg ⁵, Michael A S Jewett ⁵, Radka Lohynska ⁶, Gedske Daugaard ⁷, Stéphane Richard ^{8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20}, Agnes Chompret ^{21, 22, 23, 24, 25}, Dominique Stoppa-Lyonnet ^26, 27, 28, Catherine Bonaïti-Pellié ^22, 29, 30, Axel Heidenreich ³¹, Peter Albers ³², Edith Olah ^33, 34, Lajos Geczi ³³, Istvan Bodrogi ³³, Peter A Daly ³⁵, Parry Guilford ³⁶, Sophie D Fosså ³⁷, Ketil Heimdal ³⁷, Sergei A Tjulandin ³⁸, Ludmila Liubchenko ³⁸, Hans Stoll ^39, 40, Walter Weber ^39, 41, 42, Lawrence Einhorn ⁴³, Mary McMaster ⁴⁴, Larissa Korde, Mark H Greene ⁴⁴, Katherine L Nathanson ⁴⁵, Victoria Cortessis ⁴⁶, Douglas F Easton ^47, 48, D Timothy Bishop ⁴⁹, Michael R Stratton ¹, Elizabeth A Rapley ¹

Genes Chromosomes and Cancer / GENES CHROMOSOMES & CANCER 47, 3 (2008) 247-52

Abstract: A base substitution in the mouse Dnd1 gene resulting in a truncated Dnd protein has been shown to be responsible for germ cell loss and the development of testicular germ cell tumors (TGCT) in the 129 strain of mice. We investigated the human orthologue of this gene in 263 patients (165 with a family history of TGCT and 98 without) and found a rare heterozygous variant, p. Glu86Ala, in a single case. This variant was not present in control chromosomes (0/4,132). Analysis of the variant in an additional 842 index TGCT cases (269 with a family history of TGCT and 573 without) did not reveal any additional instances. The variant, p. Glu86Ala, is within a known functional domain of DND1 and is highly conserved through evolution. Although the variant may be a rare polymorphism, a change at such a highly conserved residue is characteristic of a disease-causing variant. Whether it is disease-causing or not, mutations in DND1 make, at most, a very small contribution to TGCT susceptibility in adults and adolescents.

1: Section of Cancer Genetics
Institute of cancer research
2: Academic Radiotherapy Unit
Institute of cancer research
3: Dept of Medical Oncology, Division of Medicine
Prince of Wales Hospital Randwick – University of New South Wales
4: Dept of Haematology and Medical Oncology
Peter MacCallum Cancer Centre
5: Princess Margaret Hospital
Princess Margaret Hospital – University of Toronto
6: Dept of Radiotherapy and Oncology
University hospital of Prague
7: Dept of Oncology
Rigshospitalet
8: Laboratoire Charles Fabry de l'Institut d'Optique (LCFIO)
Institut d'Optique Graduate School (IOGS) – CNRS : UMR8501 – Université Paris XI - Paris Sud
9: Thales Research and Technologies [Orsay] (TRT)
THALES
10: Institut d'Electronique Fondamentale
Aucune
11: Centre lillois d'études et de recherches sociologiques et économiques (CLERSE)
CNRS : UMR8019 – Université Lille I - Sciences et technologies
12: Physiopathologie cardiovasculaire
INSERM : U637 – IFR3 – Université Montpellier I
13: Laboratoire d'analyse et d'architecture des systèmes (LAAS)
CNRS : UPR8001 – Université Paul Sabatier [UPS] - Toulouse III – Institut National Polytechnique de Toulouse - INPT – Institut National des Sciences Appliquées (INSA) - Toulouse
14: Institut Camille Jordan (ICJ)
CNRS : UMR5208 – Université Claude Bernard - Lyon I – Ecole Centrale de Lyon – Institut National des Sciences Appliquées (INSA) - Lyon
15: Génétique oncologique (GO)
CNRS : UMR8125 – Institut Gustave Roussy – Université Paris XI - Paris Sud
16: Service d'urologie
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Bicêtre – Université Paris XI - Paris Sud
17: Laboratoire d'aérologie (LA)
CNRS : UMR5560 – Observatoire Midi-Pyrénées – INSU – Université Paul Sabatier [UPS] - Toulouse III
18: Centre de Recherches Biologiques
CERB
19: Génomes et cancer (GC)
CNRS : FRE2939 – Institut Gustave Roussy – Université Paris XI - Paris Sud
20: IFP Energies Nouvelles (IFPEN)
IFP Energies Nouvelles
21: Département de Pédiatrie
Institut Gustave Roussy
22: Epidémiologie des cancers
INSERM : U521
23: Consultation d'Oncogénétique
Institut Gustave Roussy – Département de médecine
24: Département de médecine
Institut Gustave Roussy
25: Département d'oncologie
Institut Gustave Roussy
26: Service de Génétique Oncologique
Institut Curie – Université Paris V - Paris Descartes
27: Département de génétique
Institut Curie
28: Unité de génétique et biologie des cancers
INSERM : U830 – Institut Curie – Université Pierre et Marie Curie [UPMC] - Paris VI
29: Génétique épidémiologique et structures des populations humaines
INSERM : U535 – IFR69 – Université Paris XI - Paris Sud
30: Epidémiologie génétique
INSERM : U155
31: Dept of Urological Oncology
Phillips university
32: Department of Urology
Klinikum Kassel GmbH
33: Department of Molecular Genetics and Department of Chemotherapy
National Institute of Oncology
34: National Institute of Oncology
National Institute of Oncology
35: Department of Medical Oncology
St James's hospital
36: Cancer Genetics Laboratory
University of Otago
37: Departments of Clinical Cancer Research and genetics
Rikshospitalet-Radiumhospitalet Trust
38: Laboratory of Clinical Genetics
Institute of Clinical Oncology
39: Medical Oncology
University hospital of Basel
40: Max Planck Institute für Metallforschung
Max-Planck-Institut
41: Google Inc.®
Google Inc.®
42: Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS)
CNRS : UMR7504 – Université Louis Pasteur - Strasbourg I
43: Department of Medical Oncology
Barts and The London Queen Mary's School of Medicine
44: Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics
NIH – National Cancer Institute
45: Depts of Medicine and Biostatistics and Epidemology
Abramson Family Cancer Research Institute – University of Pennsylvania School of Medicine
46: Department of Preventive Medicine
Keck School of Medicine
47: Cancer Research U.K. Genetic Epidemiology Unit
Strangeways Research Laboratory
48: Genetic Epidemiology Unit, Department of Public Health and Primary Care
University of Cambridge
49: Genetic Epidemiology Division, Cancer Research UK Clinical Centre
Saint James's University Hospital

hal-00281481, version 1
http://hal.archives-ouvertes.fr/hal-00281481
oai:hal.archives-ouvertes.fr:hal-00281481
From: Christelle Bouchot <>
Submitted on: Thursday, 22 May 2008 15:47:44
Updated on: Friday, 15 October 2010 14:15:52

See detailed view

Associated documents

PubMed: 18069663

PubMed Central: 3109865

DOI: 10.1002/gcc.20526

Export

Bibtex EndNote TEI RefWorks

%% hal-00281481, version 1
%% http://hal.archives-ouvertes.fr/hal-00281481
@article{linger:hal-00281481,
    hal_id = {hal-00281481},
    url = {http://hal.archives-ouvertes.fr/hal-00281481},
    title = {{Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.}},
    author = {Linger, Rachel and Dudakia, Darshna and Huddart, Robert and Tucker, Kathy and Friedlander, Michael and Phillips, Kelly-Anne and Hogg, David and Jewett, Michael A S and Lohynska, Radka and Daugaard, Gedske and Richard, St{\'e}phane and Chompret, Agnes and Stoppa-Lyonnet, Dominique and Bona{\"\i}ti-Pelli{\'e}, Catherine and Heidenreich, Axel and Albers, Peter and Olah, Edith and Geczi, Lajos and Bodrogi, Istvan and Daly, Peter A and Guilford, Parry and Foss{\aa}, Sophie D and Heimdal, Ketil and Tjulandin, Sergei A and Liubchenko, Ludmila and Stoll, Hans and Weber, Walter and Einhorn, Lawrence and McMaster, Mary and Korde, Larissa and Greene, Mark H and Nathanson, Katherine L and Cortessis, Victoria and Easton, Douglas F and Bishop, D Timothy and Stratton, Michael R and Rapley, Elizabeth A},
    abstract = {{A base substitution in the mouse Dnd1 gene resulting in a truncated Dnd protein has been shown to be responsible for germ cell loss and the development of testicular germ cell tumors (TGCT) in the 129 strain of mice. We investigated the human orthologue of this gene in 263 patients (165 with a family history of TGCT and 98 without) and found a rare heterozygous variant, p. Glu86Ala, in a single case. This variant was not present in control chromosomes (0/4,132). Analysis of the variant in an additional 842 index TGCT cases (269 with a family history of TGCT and 573 without) did not reveal any additional instances. The variant, p. Glu86Ala, is within a known functional domain of DND1 and is highly conserved through evolution. Although the variant may be a rare polymorphism, a change at such a highly conserved residue is characteristic of a disease-causing variant. Whether it is disease-causing or not, mutations in DND1 make, at most, a very small contribution to TGCT susceptibility in adults and adolescents.}},
    language = {English},
    affiliation = {Section of Cancer Genetics , Academic Radiotherapy Unit , Dept of Medical Oncology, Division of Medicine , Dept of Haematology and Medical Oncology , Princess Margaret Hospital , Dept of Radiotherapy and Oncology , Dept of Oncology , Laboratoire Charles Fabry de l'Institut d'Optique - LCFIO , Thales Research and Technologies [Orsay] - TRT , Institut d'Electronique Fondamentale , Centre lillois d'{\'e}tudes et de recherches sociologiques et {\'e}conomiques - CLERSE , Physiopathologie cardiovasculaire , Laboratoire d'analyse et d'architecture des syst{\`e}mes - LAAS , Institut Camille Jordan - ICJ , G{\'e}n{\'e}tique oncologique - GO , Service d'urologie , Laboratoire d'a{\'e}rologie - LA , Centre de Recherches Biologiques , G{\'e}nomes et cancer - GC , IFP Energies Nouvelles - IFPEN , D{\'e}partement de P{\'e}diatrie , Epid{\'e}miologie des cancers , Consultation d'Oncog{\'e}n{\'e}tique , D{\'e}partement de m{\'e}decine , D{\'e}partement d'oncologie , Service de G{\'e}n{\'e}tique Oncologique , D{\'e}partement de g{\'e}n{\'e}tique , Unit{\'e} de g{\'e}n{\'e}tique et biologie des cancers , G{\'e}n{\'e}tique {\'e}pid{\'e}miologique et structures des populations humaines , Epid{\'e}miologie g{\'e}n{\'e}tique , Dept of Urological Oncology , Department of Urology , Department of Molecular Genetics and Department of Chemotherapy , National Institute of Oncology , Department of Medical Oncology , Cancer Genetics Laboratory , Departments of Clinical Cancer Research and genetics , Laboratory of Clinical Genetics , Medical Oncology , Max Planck Institute f{\"u}r Metallforschung , Google Inc.® , Institut de Physique et Chimie des Mat{\'e}riaux de Strasbourg - IPCMS , Clinical Genetics Branch, Division of Cancer Epidemiology \& Genetics , Depts of Medicine and Biostatistics and Epidemology , Department of Preventive Medicine , Cancer Research U.K. Genetic Epidemiology Unit , Genetic Epidemiology Unit, Department of Public Health and Primary Care , Genetic Epidemiology Division, Cancer Research UK Clinical Centre},
    pages = {247-52},
    journal = {Genes Chromosomes and Cancer / GENES CHROMOSOMES \& CANCER},
    volume = {47},
    number = {3 },
    audience = {not specified },
    doi = {10.1002/gcc.20526 },
    year = {2008},
    month = Mar,
}

%F hal-00281481, version 1
%0 Journal Article
%U http://hal.archives-ouvertes.fr/hal-00281481
%2 SDV:OT
%T Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.
%A Linger, Rachel
%A Dudakia, Darshna
%A Huddart, Robert
%A Tucker, Kathy
%A Friedlander, Michael
%A Phillips, Kelly-Anne
%A Hogg, David
%A Jewett, Michael A S
%A Lohynska, Radka
%A Daugaard, Gedske
%A Richard, Stéphane
%A Chompret, Agnes
%A Stoppa-Lyonnet, Dominique
%A Bonaïti-Pellié, Catherine
%A Heidenreich, Axel
%A Albers, Peter
%A Olah, Edith
%A Geczi, Lajos
%A Bodrogi, Istvan
%A Daly, Peter A
%A Guilford, Parry
%A Fosså, Sophie D
%A Heimdal, Ketil
%A Tjulandin, Sergei A
%A Liubchenko, Ludmila
%A Stoll, Hans
%A Weber, Walter
%A Einhorn, Lawrence
%A McMaster, Mary
%A Korde, Larissa
%A Greene, Mark H
%A Nathanson, Katherine L
%A Cortessis, Victoria
%A Easton, Douglas F
%A Bishop, D Timothy
%A Stratton, Michael R
%A Rapley, Elizabeth A
%+ Section of Cancer Genetics , Academic Radiotherapy Unit , Dept of Medical Oncology, Division of Medicine , Dept of Haematology and Medical Oncology , Princess Margaret Hospital , Dept of Radiotherapy and Oncology , Dept of Oncology , Laboratoire Charles Fabry de l'Institut d'Optique - LCFIO , Thales Research and Technologies [Orsay] - TRT , Institut d'Electronique Fondamentale , Centre lillois d'études et de recherches sociologiques et économiques - CLERSE , Physiopathologie cardiovasculaire , Laboratoire d'analyse et d'architecture des systèmes - LAAS , Institut Camille Jordan - ICJ , Génétique oncologique - GO , Service d'urologie , Laboratoire d'aérologie - LA , Centre de Recherches Biologiques , Génomes et cancer - GC , IFP Energies Nouvelles - IFPEN , Département de Pédiatrie , Epidémiologie des cancers , Consultation d'Oncogénétique , Département de médecine , Département d'oncologie , Service de Génétique Oncologique , Département de génétique , Unité de génétique et biologie des cancers , Génétique épidémiologique et structures des populations humaines , Epidémiologie génétique , Dept of Urological Oncology , Department of Urology , Department of Molecular Genetics and Department of Chemotherapy , National Institute of Oncology , Department of Medical Oncology , Cancer Genetics Laboratory , Departments of Clinical Cancer Research and genetics , Laboratory of Clinical Genetics , Medical Oncology , Max Planck Institute für Metallforschung , Google Inc.® , Institut de Physique et Chimie des Matériaux de Strasbourg - IPCMS , Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics , Depts of Medicine and Biostatistics and Epidemology , Department of Preventive Medicine , Cancer Research U.K. Genetic Epidemiology Unit , Genetic Epidemiology Unit, Department of Public Health and Primary Care , Genetic Epidemiology Division, Cancer Research UK Clinical Centre
%X A base substitution in the mouse Dnd1 gene resulting in a truncated Dnd protein has been shown to be responsible for germ cell loss and the development of testicular germ cell tumors (TGCT) in the 129 strain of mice. We investigated the human orthologue of this gene in 263 patients (165 with a family history of TGCT and 98 without) and found a rare heterozygous variant, p. Glu86Ala, in a single case. This variant was not present in control chromosomes (0/4,132). Analysis of the variant in an additional 842 index TGCT cases (269 with a family history of TGCT and 573 without) did not reveal any additional instances. The variant, p. Glu86Ala, is within a known functional domain of DND1 and is highly conserved through evolution. Although the variant may be a rare polymorphism, a change at such a highly conserved residue is characteristic of a disease-causing variant. Whether it is disease-causing or not, mutations in DND1 make, at most, a very small contribution to TGCT susceptibility in adults and adolescents.
%G English
%R 10.1002/gcc.20526
%J Genes Chromosomes and Cancer / GENES CHROMOSOMES & CANCER
%2 not specified
%8 2008-03-00
%V 47
%N 3
%P 247-52
%K DNA Mutational Analysis; Family Health; Genetic Predisposition to Disease; Humans; Male; Mutation; Neoplasm Proteins; Neoplasms, Germ Cell and Embryonal; Polymerase Chain Reaction; Testicular Neoplasms

<?xml version="1.0" encoding="UTF-8"?>
<listBibl xmlns="http://www.tei-c.org/ns/1.0" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<listBibl type="article"><head>Articles in peer-reviewed journal</head>
<biblStruct type="article" xml:id="hal-00281481"><analytic>
<author><persName><forename>Rachel</forename><surname>Linger</surname></persName>
<affiliation>
<orgName type="team">Section of Cancer Genetics</orgName>
<country>GB</country>
<orgName type="institution">Institute of cancer research</orgName>
</affiliation>
</author>
<author><persName><forename>Darshna</forename><surname>Dudakia</surname></persName>
<affiliation>
<orgName type="team">Section of Cancer Genetics</orgName>
<country>GB</country>
<orgName type="institution">Institute of cancer research</orgName>
</affiliation>
</author>
<author><persName><forename>Robert</forename><surname>Huddart</surname></persName>
<affiliation>
<orgName type="team">Academic Radiotherapy Unit</orgName>
<country>GB</country>
<orgName type="institution">Institute of cancer research</orgName>
</affiliation>
</author>
<author><persName><forename>Kathy</forename><surname>Tucker</surname></persName>
<affiliation>
<orgName type="team">Dept of Medical Oncology, Division of Medicine</orgName>
<country>AU</country>
<orgName type="institution">Prince of Wales Hospital Randwick</orgName>
<orgName type="institution">University of New South Wales</orgName>
</affiliation>
</author>
<author><persName><forename>Michael</forename><surname>Friedlander</surname></persName>
<affiliation>
<orgName type="team">Dept of Medical Oncology, Division of Medicine</orgName>
<country>AU</country>
<orgName type="institution">Prince of Wales Hospital Randwick</orgName>
<orgName type="institution">University of New South Wales</orgName>
</affiliation>
</author>
<author><persName><forename>Kelly-Anne</forename><surname>Phillips</surname></persName>
<affiliation>
<orgName type="team">Dept of Haematology and Medical Oncology</orgName>
<country>AU</country>
<orgName type="institution">Peter MacCallum Cancer Centre</orgName>
</affiliation>
</author>
<author><persName><forename>David</forename><surname>Hogg</surname></persName>
<affiliation>
<orgName type="team">Princess Margaret Hospital</orgName>
<country>CA</country>
<orgName type="institution">Princess Margaret Hospital</orgName>
<orgName type="institution">University of Toronto</orgName>
</affiliation>
</author>
<author><persName><forename>Michael A S</forename><surname>Jewett</surname></persName>
<affiliation>
<orgName type="team">Princess Margaret Hospital</orgName>
<country>CA</country>
<orgName type="institution">Princess Margaret Hospital</orgName>
<orgName type="institution">University of Toronto</orgName>
</affiliation>
</author>
<author><persName><forename>Radka</forename><surname>Lohynska</surname></persName>
<affiliation>
<orgName type="team">Dept of Radiotherapy and Oncology</orgName>
<country>CZ</country>
<orgName type="institution">University hospital of Prague</orgName>
</affiliation>
</author>
<author><persName><forename>Gedske</forename><surname>Daugaard</surname></persName>
<affiliation>
<orgName type="team">Dept of Oncology</orgName>
<country>DK</country>
<orgName type="institution">Rigshospitalet</orgName>
</affiliation>
</author>
<author><persName><forename>Stéphane</forename><surname>Richard</surname></persName>
<affiliation>
<orgName type="laboratory">LCFIO</orgName>
<orgName type="team">Laboratoire Charles Fabry de l'Institut d'Optique</orgName>
<country>FR</country>
<orgName type="institution">Institut d'Optique Graduate School (IOGS)</orgName>
<orgName type="institution">CNRS : UMR8501</orgName>
<orgName type="institution">Université Paris XI - Paris Sud</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">TRT</orgName>
<orgName type="team">Thales Research and Technologies [Orsay]</orgName>
<country>FR</country>
<orgName type="institution">THALES</orgName>
</affiliation>
<affiliation>
<orgName type="team">Institut d'Electronique Fondamentale</orgName>
<country/>
<orgName type="institution">Aucune</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">CLERSE</orgName>
<orgName type="team">Centre lillois d'études et de recherches sociologiques et économiques</orgName>
<country>FR</country>
<orgName type="institution">CNRS : UMR8019</orgName>
<orgName type="institution">Université Lille I - Sciences et technologies</orgName>
</affiliation>
<affiliation>
<orgName type="team">Physiopathologie cardiovasculaire</orgName>
<country>FR</country>
<orgName type="institution">INSERM : U637</orgName>
<orgName type="institution">IFR3</orgName>
<orgName type="institution">Université Montpellier I</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">LAAS</orgName>
<orgName type="team">Laboratoire d'analyse et d'architecture des systèmes</orgName>
<country>FR</country>
<orgName type="institution">CNRS : UPR8001</orgName>
<orgName type="institution">Université Paul Sabatier [UPS] - Toulouse III</orgName>
<orgName type="institution">Institut National Polytechnique de Toulouse - INPT</orgName>
<orgName type="institution">Institut National des Sciences Appliquées (INSA) - Toulouse</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">ICJ</orgName>
<orgName type="team">Institut Camille Jordan</orgName>
<country>FR</country>
<orgName type="institution">CNRS : UMR5208</orgName>
<orgName type="institution">Université Claude Bernard - Lyon I</orgName>
<orgName type="institution">Ecole Centrale de Lyon</orgName>
<orgName type="institution">Institut National des Sciences Appliquées (INSA) - Lyon</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">GO</orgName>
<orgName type="team">Génétique oncologique</orgName>
<country>FR</country>
<orgName type="institution">CNRS : UMR8125</orgName>
<orgName type="institution">Institut Gustave Roussy</orgName>
<orgName type="institution">Université Paris XI - Paris Sud</orgName>
</affiliation>
<affiliation>
<orgName type="team">Service d'urologie</orgName>
<country>FR</country>
<orgName type="institution">Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
<orgName type="institution">Hôpital Bicêtre</orgName>
<orgName type="institution">Université Paris XI - Paris Sud</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">LA</orgName>
<orgName type="team">Laboratoire d'aérologie</orgName>
<country>FR</country>
<orgName type="institution">CNRS : UMR5560</orgName>
<orgName type="institution">Observatoire Midi-Pyrénées</orgName>
<orgName type="institution">INSU</orgName>
<orgName type="institution">Université Paul Sabatier [UPS] - Toulouse III</orgName>
</affiliation>
<affiliation>
<orgName type="team">Centre de Recherches Biologiques</orgName>
<country>FR</country>
<orgName type="institution">CERB</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">GC</orgName>
<orgName type="team">Génomes et cancer</orgName>
<country>FR</country>
<orgName type="institution">CNRS : FRE2939</orgName>
<orgName type="institution">Institut Gustave Roussy</orgName>
<orgName type="institution">Université Paris XI - Paris Sud</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">IFPEN</orgName>
<orgName type="team">IFP Energies Nouvelles</orgName>
<country>FR</country>
<orgName type="institution">IFP Energies Nouvelles</orgName>
</affiliation>
</author>
<author><persName><forename>Agnes</forename><surname>Chompret</surname></persName>
<affiliation>
<orgName type="team">Département de Pédiatrie</orgName>
<country>FR</country>
<orgName type="institution">Institut Gustave Roussy</orgName>
</affiliation>
<affiliation>
<orgName type="team">Epidémiologie des cancers</orgName>
<country>FR</country>
<orgName type="institution">INSERM : U521</orgName>
</affiliation>
<affiliation>
<orgName type="team">Consultation d'Oncogénétique</orgName>
<country>FR</country>
<orgName type="institution">Institut Gustave Roussy</orgName>
<orgName type="institution">Département de médecine</orgName>
</affiliation>
<affiliation>
<orgName type="team">Département de médecine</orgName>
<country>FR</country>
<orgName type="institution">Institut Gustave Roussy</orgName>
</affiliation>
<affiliation>
<orgName type="team">Département d'oncologie</orgName>
<country>FR</country>
<orgName type="institution">Institut Gustave Roussy</orgName>
</affiliation>
</author>
<author><persName><forename>Dominique</forename><surname>Stoppa-Lyonnet</surname></persName>
<affiliation>
<orgName type="team">Service de Génétique Oncologique</orgName>
<country>FR</country>
<orgName type="institution">Institut Curie</orgName>
<orgName type="institution">Université Paris V - Paris Descartes</orgName>
</affiliation>
<affiliation>
<orgName type="team">Département de génétique</orgName>
<country>FR</country>
<orgName type="institution">Institut Curie</orgName>
</affiliation>
<affiliation>
<orgName type="team">Unité de génétique et biologie des cancers</orgName>
<country>FR</country>
<orgName type="institution">INSERM : U830</orgName>
<orgName type="institution">Institut Curie</orgName>
<orgName type="institution">Université Pierre et Marie Curie [UPMC] - Paris VI</orgName>
</affiliation>
</author>
<author><persName><forename>Catherine</forename><surname>Bonaïti-Pellié</surname></persName>
<affiliation>
<orgName type="team">Epidémiologie des cancers</orgName>
<country>FR</country>
<orgName type="institution">INSERM : U521</orgName>
</affiliation>
<affiliation>
<orgName type="team">Génétique épidémiologique et structures des populations humaines</orgName>
<country>FR</country>
<orgName type="institution">INSERM : U535</orgName>
<orgName type="institution">IFR69</orgName>
<orgName type="institution">Université Paris XI - Paris Sud</orgName>
</affiliation>
<affiliation>
<orgName type="team">Epidémiologie génétique</orgName>
<country>FR</country>
<orgName type="institution">INSERM : U155</orgName>
</affiliation>
</author>
<author><persName><forename>Axel</forename><surname>Heidenreich</surname></persName>
<affiliation>
<orgName type="team">Dept of Urological Oncology</orgName>
<country>DE</country>
<orgName type="institution">Phillips university</orgName>
</affiliation>
</author>
<author><persName><forename>Peter</forename><surname>Albers</surname></persName>
<affiliation>
<orgName type="team">Department of Urology</orgName>
<country>DE</country>
<orgName type="institution">Klinikum Kassel GmbH</orgName>
</affiliation>
</author>
<author><persName><forename>Edith</forename><surname>Olah</surname></persName>
<affiliation>
<orgName type="team">Department of Molecular Genetics and Department of Chemotherapy</orgName>
<country>HU</country>
<orgName type="institution">National Institute of Oncology</orgName>
</affiliation>
<affiliation>
<orgName type="team">National Institute of Oncology</orgName>
<country>HU</country>
<orgName type="institution">National Institute of Oncology</orgName>
</affiliation>
</author>
<author><persName><forename>Lajos</forename><surname>Geczi</surname></persName>
<affiliation>
<orgName type="team">Department of Molecular Genetics and Department of Chemotherapy</orgName>
<country>HU</country>
<orgName type="institution">National Institute of Oncology</orgName>
</affiliation>
</author>
<author><persName><forename>Istvan</forename><surname>Bodrogi</surname></persName>
<affiliation>
<orgName type="team">Department of Molecular Genetics and Department of Chemotherapy</orgName>
<country>HU</country>
<orgName type="institution">National Institute of Oncology</orgName>
</affiliation>
</author>
<author><persName><forename>Peter A</forename><surname>Daly</surname></persName>
<affiliation>
<orgName type="team">Department of Medical Oncology</orgName>
<country>IE</country>
<orgName type="institution">St James's hospital</orgName>
</affiliation>
</author>
<author><persName><forename>Parry</forename><surname>Guilford</surname></persName>
<affiliation>
<orgName type="team">Cancer Genetics Laboratory</orgName>
<country>NZ</country>
<orgName type="institution">University of Otago</orgName>
</affiliation>
</author>
<author><persName><forename>Sophie D</forename><surname>Fosså</surname></persName>
<affiliation>
<orgName type="team">Departments of Clinical Cancer Research and genetics</orgName>
<country>NO</country>
<orgName type="institution">Rikshospitalet-Radiumhospitalet Trust</orgName>
</affiliation>
</author>
<author><persName><forename>Ketil</forename><surname>Heimdal</surname></persName>
<affiliation>
<orgName type="team">Departments of Clinical Cancer Research and genetics</orgName>
<country>NO</country>
<orgName type="institution">Rikshospitalet-Radiumhospitalet Trust</orgName>
</affiliation>
</author>
<author><persName><forename>Sergei A</forename><surname>Tjulandin</surname></persName>
<affiliation>
<orgName type="team">Laboratory of Clinical Genetics</orgName>
<country>RU</country>
<orgName type="institution">Institute of Clinical Oncology</orgName>
</affiliation>
</author>
<author><persName><forename>Ludmila</forename><surname>Liubchenko</surname></persName>
<affiliation>
<orgName type="team">Laboratory of Clinical Genetics</orgName>
<country>RU</country>
<orgName type="institution">Institute of Clinical Oncology</orgName>
</affiliation>
</author>
<author><persName><forename>Hans</forename><surname>Stoll</surname></persName>
<affiliation>
<orgName type="team">Medical Oncology</orgName>
<country>CH</country>
<orgName type="institution">University hospital of Basel</orgName>
</affiliation>
<affiliation>
<orgName type="team">Max Planck Institute für Metallforschung</orgName>
<country>DE</country>
<orgName type="institution">Max-Planck-Institut</orgName>
</affiliation>
</author>
<author><persName><forename>Walter</forename><surname>Weber</surname></persName>
<affiliation>
<orgName type="team">Medical Oncology</orgName>
<country>CH</country>
<orgName type="institution">University hospital of Basel</orgName>
</affiliation>
<affiliation>
<orgName type="team">Google Inc.®</orgName>
<country>US</country>
<orgName type="institution">Google Inc.®</orgName>
</affiliation>
<affiliation>
<orgName type="laboratory">IPCMS</orgName>
<orgName type="team">Institut de Physique et Chimie des Matériaux de Strasbourg</orgName>
<country>FR</country>
<orgName type="institution">CNRS : UMR7504</orgName>
<orgName type="institution">Université Louis Pasteur - Strasbourg I</orgName>
</affiliation>
</author>
<author><persName><forename>Lawrence</forename><surname>Einhorn</surname></persName>
<affiliation>
<orgName type="team">Department of Medical Oncology</orgName>
<country>GB</country>
<orgName type="institution">Barts and The London Queen Mary's School of Medicine</orgName>
</affiliation>
</author>
<author><persName><forename>Mary</forename><surname>McMaster</surname></persName>
<affiliation>
<orgName type="team">Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics</orgName>
<country>US</country>
<orgName type="institution">NIH</orgName>
<orgName type="institution">National Cancer Institute</orgName>
</affiliation>
</author>
<author><persName><forename>Larissa</forename><surname>Korde</surname></persName></author>
<author><persName><forename>Mark H</forename><surname>Greene</surname></persName>
<affiliation>
<orgName type="team">Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics</orgName>
<country>US</country>
<orgName type="institution">NIH</orgName>
<orgName type="institution">National Cancer Institute</orgName>
</affiliation>
</author>
<author><persName><forename>Katherine L</forename><surname>Nathanson</surname></persName>
<affiliation>
<orgName type="team">Depts of Medicine and Biostatistics and Epidemology</orgName>
<country>US</country>
<orgName type="institution">Abramson Family Cancer Research Institute</orgName>
<orgName type="institution">University of Pennsylvania School of Medicine</orgName>
</affiliation>
</author>
<author><persName><forename>Victoria</forename><surname>Cortessis</surname></persName>
<affiliation>
<orgName type="team">Department of Preventive Medicine</orgName>
<country>US</country>
<orgName type="institution">Keck School of Medicine</orgName>
</affiliation>
</author>
<author><persName><forename>Douglas F</forename><surname>Easton</surname></persName>
<affiliation>
<orgName type="team">Cancer Research U.K. Genetic Epidemiology Unit</orgName>
<country>GB</country>
<orgName type="institution">Strangeways Research Laboratory</orgName>
</affiliation>
<affiliation>
<orgName type="team">Genetic Epidemiology Unit, Department of Public Health and Primary Care</orgName>
<country>GB</country>
<orgName type="institution">University of Cambridge</orgName>
</affiliation>
</author>
<author><persName><forename>D Timothy</forename><surname>Bishop</surname></persName>
<affiliation>
<orgName type="team">Genetic Epidemiology Division, Cancer Research UK Clinical Centre</orgName>
<country>GB</country>
<orgName type="institution">Saint James's University Hospital</orgName>
</affiliation>
</author>
<author><persName><forename>Michael R</forename><surname>Stratton</surname></persName>
<affiliation>
<orgName type="team">Section of Cancer Genetics</orgName>
<country>GB</country>
<orgName type="institution">Institute of cancer research</orgName>
</affiliation>
</author>
<author><persName><forename>Elizabeth A</forename><surname>Rapley</surname></persName>
<affiliation>
<orgName type="team">Section of Cancer Genetics</orgName>
<country>GB</country>
<orgName type="institution">Institute of cancer research</orgName>
</affiliation>
</author>
<title type="main" level="a">Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.</title></analytic><monogr><title level="j" type="main">Genes Chromosomes and Cancer / GENES CHROMOSOMES & CANCER</title><imprint><biblScope type="publicationDate">2008-03-00</biblScope><biblScope type="vol">47</biblScope><biblScope type="issue">3</biblScope><biblScope type="pp">247-52</biblScope></imprint></monogr><idno type="doi">10.1002/gcc.20526</idno><idno type="HALid">http://hal.archives-ouvertes.fr/hal-00281481</idno></biblStruct>
</listBibl>
</listBibl>