Evidence for cardiomyocyte renewal in humans.

Olaf Bergmann; Ratan D Bhardwaj; Samuel Bernard; Sofia Zdunek; Fanie Barnabé-Heider; Stuart Walsh; Joel Zupicich; Kanar Alkass; Bruce A Buchholz; Henrik Druid; Stefan Jovinge; Jonas Frisén

hal-00374382, version 1

Evidence for cardiomyocyte renewal in humans.

Olaf Bergmann ¹, Ratan D Bhardwaj ¹, Samuel Bernard ², Sofia Zdunek ¹, Fanie Barnabé-Heider ¹, Stuart Walsh ³, Joel Zupicich ¹, Kanar Alkass ⁴, Bruce A Buchholz ⁵, Henrik Druid ⁴, Stefan Jovinge ^3, 6, Jonas Frisén ( Author to contact preferably ) ¹

Science 324, 5923 (2009) 98-102

Abstract: It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

1: Department of Cell and Molecular Biology [Sweden] (DCMB)
Medical Nobel Institute
2: Institut Camille Jordan (ICJ)
CNRS : UMR5208 – Université Claude Bernard - Lyon I – Ecole Centrale de Lyon – Institut National des Sciences Appliquées (INSA) - Lyon
3: Lund Stem Cell Center
Lund University
4: Department of Forensic Medicine [Sweden]
Karolinska Institutet
5: Center for Accelerator Mass Spectrometry
Lawrence Livermore National Laboratory
6: Department of Cardiology [Lund]
Lund University Hopsital

hal-00374382, version 1
http://hal.archives-ouvertes.fr/hal-00374382
oai:hal.archives-ouvertes.fr:hal-00374382
From: Samuel Bernard <>
Submitted on: Wednesday, 8 April 2009 14:46:49
Updated on: Wednesday, 8 April 2009 14:46:49

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PubMed: 19342590

PubMed Central: 2991140

DOI: 10.1126/science.1164680

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