hal-00376752, version 1

Structure function analysis of Leishmania sirtuin: an ensemble of in silico and biochemical studies.

Rameshwar U Kadam, Joana Tavares ^1, 2, V. M. Kiran, Anabela Cordeiro, Ali Ouaissi ^3, 4, Nilanjan Roy ^5, 6

Chemical Biology & Drug Design 71, 5 (2008) 501-6

• 1:  DOLPHIN (INRIA Futurs)
• 
  INRIA – CNRS : UMR8022 – Université Lille I - Sciences et technologies France
• 2:  Laboratoire Leibniz (Leibniz - IMAG)
• http://www-leibniz.imag.fr
  CNRS : UMR5522 – Université Joseph Fourier - Grenoble I – Institut National Polytechnique de Grenoble (INPG) 46, avenue Félix Viallet - 38031 GRENOBLE Cedex France
• 3:  Dynamique des interactions membranaires normales et pathologiques (DIMNP)
• http://www.dimnp.univ-montp2.fr
  CNRS : UMR5235 – Université Montpellier I – Université Montpellier II - Sciences et techniques BT 24 CC 107 Place Eugène Bataillon 34095 MONTPELLIER CEDEX 5 France
• 4:  Pathogénie et Epidémiologie des Trypanosomatidés (UR008)
• 
  Institut de Recherche pour le Développement France
• 5:  Department of Neuroscience (DEPARTMENT OF NEUROSCIENCE)
• 
  University of Pennsylvania Philadelphia United States
• 6:  Institut Fourier (IF)
• http://www-fourier.ujf-grenoble.fr/
  CNRS : UMR5582 – Université Joseph Fourier - Grenoble I France

Bibliographic reference

• Type of document: Articles in peer-reviewed journal
• Subject: Life Sciences/Biochemistry, Molecular Biology
• PMID (PubMed ID): (18373547)
• Title: Structure function analysis of Leishmania sirtuin: an ensemble of in silico and biochemical studies.
• Abstract: Novel anti-leishmanial target LmSir2 has few subtle but prudent structural differences in ligand binding and catalytic domain as compared to its human counterpart. In silico screening and validation followed by in vitro deacetylation and cell killing assays described herein give a proof of concept for development of strategies exploiting such minor differences for screening libraries of small molecules to identify selective inhibitors.
• Fulltext language: English
• DOI: 10.1111/j.1747-0285.2008.00652.x
• Journal: Chemical Biology & Drug Design
• Audience: international
• Publication date: 2008-05
• Submission date: 2008-03-27
• Volume: 71
• Issue: 5
• Page, identifiant, ...: 501-6
• MeSH Classification: Animals – Antiprotozoal Agents – Binding Sites – Catalytic Domain – Cell Death – Drug Evaluation – Preclinical – Enzyme Inhibitors – Humans – Leishmania – Quantitative Structure-Activity Relationship – Sirtuins

• hal-00376752, version 1
• http://hal.archives-ouvertes.fr/hal-00376752
• oai:hal.archives-ouvertes.fr:hal-00376752
• From: Annie Bosch-Savary <>
• Submitted on: Monday, 20 April 2009 10:57:01
• Updated on: Monday, 20 April 2009 10:57:01