INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY

Sabir Jacquir; Stéphane Binczak; Binbin Xu; Gabriel Laurent; David Vandroux; Pierre Athias; Jean-Marie Bilbault

hal-00585901, version 1

INVESTIGATION OF MICRO SPIRAL WAVES AT CELLULAR LEVEL USING A MICROELECTRODE ARRAYS TECHNOLOGY

Sabir Jacquir ( Auteur à contacter de préférence ) ¹, Stéphane Binczak ¹, Binbin Xu ¹, Gabriel Laurent ¹, David Vandroux ², Pierre Athias ³, Jean-Marie Bilbault ¹

International Journal of Bifurcation and Chaos 21, 1 (2011) 209-223

Résumé : During cardiac arrhythmia, functional reentries may take the form of spiral waves. The purpose of this study was to induce spiral waves by an electrical stimulation of cultured neonatal rat cardiomyocytes using a microelectrode arrays technology. In basal conditions, cardiac muscle cells in monolayer culture displayed a planar wavefront propagation. External electrical impulse trains induced severe arrhythmia and spiral waves appeared. This in vitro generation of spiral wave opens a new way to test the anti-arrhythmic drugs and for strategies at microscopically scale.

1 : Laboratoire Electronique, Informatique et Image (Le2i)
Université de Bourgogne – Arts et Métiers ParisTech – CNRS : UMR6306
2 : NVH Medicinal (NVH)
Université de Bourgogne
3 : Laboratoire de Physiopathologie et de Pharmacologie Cardiovasculaire Expérimentale (LPPCE)
Université de Bourgogne : EA

hal-00585901, version 1
http://hal-univ-bourgogne.archives-ouvertes.fr/hal-00585901
oai:hal-univ-bourgogne.archives-ouvertes.fr:hal-00585901
Contributeur : Sabir Jacquir <>
Soumis le : Jeudi 14 Avril 2011, 10:48:21
Dernière modification le : Jeudi 14 Avril 2011, 14:23:13

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DOI : 10.1142/S0218127411028374

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