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Des agents intelligents pour l’imagerie moléculaire

Abstract : The unique properties of metal complexes with respect to their versatile magnetic and optical features, multipleoxidation states, variable charges and geometries offer rich opportunities both in diagnostics and therapy. Metal-based drugs are present in many major pharmaceutical classes in current clinical use. Among them, gadolinium(Gd3+) complexes have been successfully used since the mid-eighties as magnetic resonance imaging (MRI)contrast agents. Recent research in this field focuses on molecular imaging probes which hold the promise of MRIvisualization of different biomarkers and tissue physiological parameters. The design of such smart probes is basedon coordination chemistry concepts that use modulation of the molecular structure to produce a specificbiomarker-dependent MRI response. Some representative examples of the potential MRI assessment of enzymaticactivities, neurotransmitter concentration, or the redox state are shown. Another active field of research involvesthe replacement of Gd3+ complexes by chelates of the more biocompatible Mn2+. Here the main challengeis to create Mn2+ complexes that combine MRI efficiency, high thermodynamic stability and resistance to in vivodissociation.
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https://hal.archives-ouvertes.fr/hal-03036754
Contributor : Eva Jakab Toth <>
Submitted on : Wednesday, December 2, 2020 - 6:15:31 PM
Last modification on : Friday, December 18, 2020 - 8:29:50 AM

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Éva Tóth. Des agents intelligents pour l’imagerie moléculaire. L'Actualité Chimique, Société chimique de France, 2019, pp.11-17. ⟨hal-03036754⟩

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