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Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds

Abstract : The anti-inflammatory and antihyperglycemic effects of polysaccharides extracted from Alhagi maurorum Medik. seeds, spontaneous shrub collected in Southern of Algerian Sahara were investigated. Their water extraction followed by alcoholic precipitation was conducted to obtain two water-soluble polysaccharides extracts (WSPAM1 and WSPAM2). They were characterized using Fourier transform infrared, 1H/13C Nuclear Magnetic Resonance, Gas Chromatography-Mass Spectrometry and Size Exclusion Chromatography coupled with Multi-Angle Light Scattering. The capacity of those fractions to inhibit α-amylase activity and thermally induced Bovine Serum Albumin denaturation were also investigated. WSPAM1 and WSPAM2 were galactomannans with a mannose/galactose ratio of 2.2 and 2.4, respectively. The SEC-MALLS analysis revealed that WSPAM1 had a molecular weight of 1.4 ×106 Da. The investigations highlighted antinflammatory and antihyperglycemic effects in a dose-dependant manner of WSPAM1 and WSPAM2.
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https://hal.uca.fr/hal-03474528
Contributor : Christophe Tournayre Connect in order to contact the contributor
Submitted on : Friday, December 10, 2021 - 11:33:58 AM
Last modification on : Saturday, May 7, 2022 - 3:38:40 AM
Long-term archiving on: : Friday, March 11, 2022 - 6:55:18 PM

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Fatma Zohra Chakou, Zakaria Boual, Mohamed Didi Ould El Hadj, Hakim Belkhalfa, Khaldoun Bachari, et al.. Pharmacological Investigations in Traditional Utilization of Alhagi maurorum Medik. in Saharan Algeria: In Vitro Study of Anti-Inflammatory and Antihyperglycemic Activities of Water-Soluble Polysaccharides Extracted from the Seeds. Plants, MDPI, 2021, 10 (12), pp.2658. ⟨10.3390/plants10122658⟩. ⟨hal-03474528⟩

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