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Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus

We have recently generated the first generation of antiviral CQDs. These CQDs, derived by hydrothermal carbonization from ethylenediamine/citric acid as carbon precursors and post-modified with boronic acid ligands, showed a concentration dependent virus inactivation with an estimated EC50 of 52 ± 8 µg mL-1.

CQDs derived from 4-aminophenylboronic acid without any further modification resulted in the second-generation of anti-HCoV nanomaterials with an EC50 lowered to 5.2 ± 0.7 µg mL-1. The underlying mechanism of action of these CQDs revealed to be inhibition of HCoV-229E entry that could be due to interaction of the functional groups of the CQDs with HCoV-229E entry receptors; surprisingly, an equally large inhibition activity was observed at the viral replication step.

 

Reference: ACS Appl. Mater. Interfaces 2019, 11, 46, 42964-42974.

 

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