Skip to Main content Skip to Navigation
Journal articles

Cell-Specific Neuropharmacology

Abstract : Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking the activity of cell surface receptors and ion channels in defined neural circuits to brain states and behaviors has been a key challenge in neuroscience, since cell targeting is not possible with traditional neuropharmacology. We review here recent technologies that enable the effect of drugs to be restricted to specific cell types, thereby allowing acute manipulation of the brain’s own proteins with circuit specificity. We highlight the importance of developing cell-specific neuropharmacology strategies for decoding the nervous system with molecular and circuit precision, and for developing future therapeutics with reduced side effects.
Complete list of metadatas

Cited literature [23 references]  Display  Hide  Download

https://hal.sorbonne-universite.fr/hal-02344518
Contributor : Gestionnaire Hal-Su <>
Submitted on : Monday, November 4, 2019 - 11:01:08 AM
Last modification on : Thursday, December 10, 2020 - 11:09:33 AM
Long-term archiving on: : Wednesday, February 5, 2020 - 11:00:54 PM

File

Mondoloni et al. - 2019 - Cell...
Files produced by the author(s)

Identifiers

Citation

Sarah Mondoloni, Romain Durand-de Cuttoli, Alexandre Mourot. Cell-Specific Neuropharmacology. Trends in Pharmacological Sciences, Elsevier, 2019, 40 (9), pp.696-710. ⟨10.1016/j.tips.2019.07.007⟩. ⟨hal-02344518⟩

Share

Metrics

Record views

121

Files downloads

289