Review of the current status of RAS mutation testing in patients with metastatic colorectal cancer (mCRC): Flash-RAS study - Centre Alexis Vautrin Accéder directement au contenu
Poster De Conférence Année : 2015

Review of the current status of RAS mutation testing in patients with metastatic colorectal cancer (mCRC): Flash-RAS study

Résumé

OBJECTIVES: In 2013, it was shown that mutations in KRAS exons 3 and 4, or NRAS exons 2 to 4 had a similar effect. The primary objective was to assess the practices in conducting RAS testing in 2014. The secondary objectives were to describe the evolution of the RAS testing prescription rates from 2011, the process and time required to obtain the results, and to analyze their impact on the therapeutic strategy. METHODS: FLASH-RAS is an observational retrospective French multicenter study. RESULTS: 375 mCRC patients diagnosed and initiating a 1st line treatment (L1) between March and June 2014 were analyzed. For 90.1% of the patients (IC95%= [87.1%; 93.2%]), a genotyping request for RAS biomarkers was made in L1, i.e. a significantly increased rate compared to 2011 (81.1% in 2011, p<0.001). For 75% of the patients, the request was made before or at least one month after the diagnosis of the first metastases (1st M). No increase was observed in the median and mean times to obtain the test results between 2011 and 2014 despite the increased number of exons tested. CONCLUSIONS: In 2014, the rate of RAS genotyping requests has been increasing since 2011. For a majority of patients, the request is made before or at the latest one month after 1st M diagnosis. Nevertheless, for 24.5% of the patients, the request is made more than one month after 1st M diagnosis, which is not compatible with an informed treatment decision in L1.
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Dates et versions

hal-01241776 , version 1 (14-12-2015)

Identifiants

  • HAL Id : hal-01241776 , version 1

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Jean-Christophe Sabourin, Astrid Lièvre, Jean-Louis Merlin, Michel Ducreux, Pascal Artru, et al.. Review of the current status of RAS mutation testing in patients with metastatic colorectal cancer (mCRC): Flash-RAS study. 18th Annual European Congress of the International Society for Pharmacoeconomics and Outcome Research, ISPOR, Nov 2015, Milan, Italy. ⟨hal-01241776⟩
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