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The population firing rate in the presence of GABAergic tonic inhibition in single neurons and application to general anaesthesia

Axel Hutt 1 
1 CORTEX - Neuromimetic intelligence
INRIA Lorraine, LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications
Abstract : Tonic inhibition has been found experimentally in single neurons and a ects the activity of neural populations. This kind of inhibition is supposed to set the background or resting level of neural activity and plays a role in the brains arousal system, e.g. during general anaesthesia. The work shows how to involve tonic inhibition in population rate-coding models by deriving a novel transfer function. The analytical and numerical study of the novel transfer function reveals the impact of tonic inhibition on the population ring rate. Finally, a rst application to a recent neural eld model for general anaesthesia discusses the origin of the loss of consciousness during anaesthesia
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Submitted on : Thursday, November 10, 2011 - 3:54:26 PM
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Axel Hutt. The population firing rate in the presence of GABAergic tonic inhibition in single neurons and application to general anaesthesia. Cognitive Neurodynamics, Springer Verlag, 2012, 6 (3), pp.227-237. ⟨10.1007/s11571-011-9182-9⟩. ⟨hal-00640064⟩

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