Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.

Abstract : Nonribosomal peptides (NRPs) are molecules produced by microorganisms that have a broad spectrum of biological activities and pharmaceutical applications (e.g., antibiotic, immunomodulating, and antitumor activities). One particularity of the NRPs is the biodiversity of their monomers, extending far beyond the 20 proteogenic amino acid residues. Norine, a comprehensive database of NRPs, allowed us to review for the first time the main characteristics of the NRPs and especially their monomer biodiversity. Our analysis highlighted a significant similarity relationship between NRPs synthesized by bacteria and those isolated from metazoa, especially from sponges, supporting the hypothesis that some NRPs isolated from sponges are actually synthesized by symbiotic bacteria rather than by the sponges themselves. A comparison of peptide monomeric compositions as a function of biological activity showed that some monomers are specific to a class of activities. An analysis of the monomer compositions of peptide products predicted from genomic information (metagenomics and high-throughput genome sequencing) or of new peptides detected by mass spectrometry analysis applied to a culture supernatant can provide indications of the origin of a peptide and/or its biological activity.
Type de document :
Article dans une revue
Journal of Bacteriology, American Society for Microbiology, 2010, 192 (19), pp.5143-50. 〈10.1128/JB.00315-10〉
Liste complète des métadonnées

Littérature citée [44 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-00641488
Contributeur : Maude Pupin <>
Soumis le : lundi 20 mai 2013 - 14:19:39
Dernière modification le : mardi 6 mars 2018 - 17:40:53
Document(s) archivé(s) le : mercredi 21 août 2013 - 02:25:10

Fichier

Jbact2010.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Ségolène Caboche, Valérie Leclère, Maude Pupin, Gregory Kucherov, Philippe Jacques. Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.. Journal of Bacteriology, American Society for Microbiology, 2010, 192 (19), pp.5143-50. 〈10.1128/JB.00315-10〉. 〈hal-00641488〉

Partager

Métriques

Consultations de la notice

284

Téléchargements de fichiers

155