A THEORY of RATE CODING CONTROL by INTRINSIC PLASTICITY EFFECTS

Abstract : Intrinsic plasticity (IP) is a ubiquitous activity-dependent process regulating neuronal excitability and a cellular correlate of behavioral learning and neuronal homeostasis. Because IP is induced rapidly and maintained long-term, it likely represents a major determinant of adaptive collective neuronal dynamics. However, assessing the exact impact of IP has remained elusive. Indeed, it is extremely difficult disentangling the complex non-linear interaction between IP effects, by which conductance changes alter neuronal activity, and IP rules, whereby activity modifies conductance via signaling pathways. Moreover, the two major IP effects on firing rate, threshold and gain modulation, remain unknown in their very mechanisms. Here, using extensive simulations and sensitivity analysis of Hodgkin-Huxley models, we show that threshold and gain modulation are accounted for by maximal conductance plasticity of conductance that situate in two separate domains of the parameter space corresponding to sub- and supra threshold conductance (i.e. activating below or above the spike onset threshold potential). Analyzing equivalent integrate-and-fire models, we provide formal expressions of sensitivities relating to conductance parameters, unraveling unprecedented mechanisms governing IP effects. Our results generalize to the IP of other conductance parameters and allow strong inference for calcium-gated conductance, yielding a general picture that accounts for a large repertoire of experimental observations. The expressions we provide can be combined with IP rules in rate or spiking models, offering a general framework to systematically assess the computational consequences of IP of pharmacologically identified conductance with both fine grain description and mathematical tractability. We provide an example of such IP loop model addressing the important issue of the homeostatic regulation of spontaneous discharge. Because we do not formulate any assumptions on modification rules, the present theory is also relevant to other neural processes involving excitability changes, such as neuromodulation, development, aging and neural disorders.
Type de document :
Article dans une revue
PLoS Computational Biology, Public Library of Science, 2012, 8 (1), pp.e1002349. 〈10.1371/ journal.pcbi.1002349〉
Liste complète des métadonnées

Littérature citée [98 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-00645336
Contributeur : Hugues Berry <>
Soumis le : vendredi 20 janvier 2012 - 00:40:20
Dernière modification le : vendredi 31 août 2018 - 09:13:02
Document(s) archivé(s) le : samedi 21 avril 2012 - 02:20:40

Fichier

PLoS2012_IP.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Jérémie Naudé, Jeanne T. Paz, Hugues Berry, Bruno Delord. A THEORY of RATE CODING CONTROL by INTRINSIC PLASTICITY EFFECTS. PLoS Computational Biology, Public Library of Science, 2012, 8 (1), pp.e1002349. 〈10.1371/ journal.pcbi.1002349〉. 〈hal-00645336〉

Partager

Métriques

Consultations de la notice

528

Téléchargements de fichiers

125