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Estimation of tissue contractility from cardiac cine-MRI using a biomechanical heart model
Abstract : The objective of this paper is to propose and assess an estimation procedure - based on data assimilation principles - well-suited to obtain some regional values of key biophysical parameters in a beating heart model, using actual Cine-MR images. The motivation is twofold: (1) to provide an automatic tool for personalizing the characteristics of a cardiac model in order to achieve predictivity in patient-specific modeling, and (2) to obtain some useful information for diagnosis purposes in the estimated quantities themselves. In order to assess the global methodology we specifically devised an animal experiment in which a controlled infarct was produced and data acquired before and after infarction, with an estimation of regional tissue contractility - a key parameter directly affected by the pathology - performed for every measured stage. After performing a preliminary assessment of our proposed methodology using synthetic data, we then demonstrate a full-scale application by first estimating contractility values associated with 6 regions based on the AHA subdivision, before running a more detailed estimation using the actual AHA segments. The estimation results are assessed by comparison with the medical knowledge of the specific infarct, and with late enhancement MR images. We discuss their accuracy at the various subdivision levels, in the light of the inherent modeling limitations and of the intrinsic information contents featured in the data.
Cited literature [52 references]
https://hal.inria.fr/hal-00654541
Contributor : Dominique Chapelle <>
Submitted on : Thursday, December 22, 2011 - 11:15:31 AM
Last modification on : Friday, January 10, 2020 - 12:42:03 PM
Document(s) archivé(s) le : Monday, November 19, 2012 - 11:45:10 AM
Contributor : Dominique Chapelle <>
Submitted on : Thursday, December 22, 2011 - 11:15:31 AM
Last modification on : Friday, January 10, 2020 - 12:42:03 PM
Document(s) archivé(s) le : Monday, November 19, 2012 - 11:45:10 AM
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cardiacPigEstim.pdf
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