Integrating Diverse Reaction Types into Stochastic Models - A Signaling Pathway Case Study in the Imperative Pi-Calculus

Abstract : We present a case study of reusing parameters and reactions of a deterministic model of a biochemical system in order to implement a stochastic one. Our investigations base on a model of the Wnt signaling pathway and aim to study the influence of the cell cycle on the pathway's dynamics. We report on our approaches to solve two major challenges: one is to gather and convert kinetic model parameters, e.g. constants for diffusion and enzymatic reactions. The second challenge is to provide the first implementation of reactions that exhibit Michaelis-Menten kinetics into a pi-calculus based approach by deploying the imperative pi-calculus.
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Communication dans un congrès
Winter Simulation Conference (WSC) '09, Dec 2009, Austin, Texas, United States. 2009, 〈10.1109/WSC.2009.5429723〉
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Dernière modification le : mercredi 30 mai 2012 - 19:18:48
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Orianne Mazemondet, Mathias John, Carsten Maus, Stefan Leye, Adelinde Uhrmacher, et al.. Integrating Diverse Reaction Types into Stochastic Models - A Signaling Pathway Case Study in the Imperative Pi-Calculus. Winter Simulation Conference (WSC) '09, Dec 2009, Austin, Texas, United States. 2009, 〈10.1109/WSC.2009.5429723〉. 〈hal-00656195〉

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