NRPS toolbox for the discovery of new nonribosomal peptides and synthetases

Maude Pupin 1, 2 Malika Smaïl-Tabbone 3 Philippe Jacques 4 Marie-Dominique Devignes 3, * Valérie Leclère 4
* Corresponding author
2 BONSAI - Bioinformatics and Sequence Analysis
LIFL - Laboratoire d'Informatique Fondamentale de Lille, Inria Lille - Nord Europe
3 ORPAILLEUR - Knowledge representation, reasonning
Inria Nancy - Grand Est, LORIA - NLPKD - Department of Natural Language Processing & Knowledge Discovery
Abstract : Nonribosomal peptide synthetases are huge multi-enzymatic complexes synthesizing peptides, but not through the classical process of transcription and then translation. The synthetases are organised in modules, each one integrating an amino acid in the final peptide. The modules are divided in domains providing specialized activities. So, those enzymes are as diverse as their products. We present our toolbox designed to annotate them accurately and promising results obtained on some Burkholderia, Bacillus and Pseudomonas genomes.
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Submitted on : Friday, September 21, 2012 - 1:49:51 PM
Last modification on : Thursday, February 21, 2019 - 10:52:54 AM
Long-term archiving on : Saturday, December 22, 2012 - 3:37:03 AM

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Maude Pupin, Malika Smaïl-Tabbone, Philippe Jacques, Marie-Dominique Devignes, Valérie Leclère. NRPS toolbox for the discovery of new nonribosomal peptides and synthetases. Journées Ouvertes en Biologie, l'Informatique et les Mathématiques - JOBIM 2012, Jul 2012, Rennes, France. pp.89-93. ⟨hal-00734312⟩

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