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Journal articles
Rhea--a manually curated resource of biochemical reactions.
Rafael Alcântara
1
Kristian B Axelsen
1
Anne Morgat
2
Eugeni Belda
1
Elisabeth Coudert
1
Alan Bridge
1
Hong Cao
1
Paula de Matos
1
Marcus Ennis
1
Steve Turner
1, 3
Gareth Owen
1
Lydie Bougueleret
1
Ioannis Xenarios
1
Christoph Steinbeck
1
2
BAMBOO - An algorithmic view on genomes, cells, and environments
Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Ioannis Xenarios 1
Author
Christoph Steinbeck 1
Author
1
Swiss-Prot Group (SIB Swiss Institute of Bioinformatics - Switzerland)
- SIB - Swiss Institute of Bioinformatics [Genève] (rue Michel-Servet 1, 1211 Geneva 4 - Switzerland)
2
BAMBOO - An algorithmic view on genomes, cells, and environments (Laboratoire de Biométrie et Biologie Évolutive. UMR CNRS 5558 Campus de La Doua - Université Claude Bernard - Lyon 1 Bâtiment Grégoire Mendel - 16 rue Raphael Dubois 69 100 Villeurbanne -- INRIA Grenoble - Rhône-Alpes Inovallée 655 avenue de l'Europe -Montbonnot 38 334 Saint Ismier Cedex France - France)
- Inria Grenoble - Rhône-Alpes (Inovallée
655 avenue de l'Europe
38330 Montbonnot - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
- LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (43 Bld du 11 Novembre 1918 69622 VILLEURBANNE CEDEX - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- Inria - Institut National de Recherche en Informatique et en Automatique (Domaine de Voluceau Rocquencourt - BP 105 78153 Le Chesnay Cedex - France)
- VAS - VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique) - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5558 (France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
3
Department of Clinical Biochemistry (SAS Laboratory Department of Clinical Biochemistry Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP - United Kingdom)
- Royal Victoria Infirmary (France)
Abstract : Rhea (http://www.ebi.ac.uk/rhea) is a comprehensive resource of expert-curated biochemical reactions. Rhea provides a non-redundant set of chemical transformations for use in a broad spectrum of applications, including metabolic network reconstruction and pathway inference. Rhea includes enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list), transport reactions and spontaneously occurring reactions. Rhea reactions are described using chemical species from the Chemical Entities of Biological Interest ontology (ChEBI) and are stoichiometrically balanced for mass and charge. They are extensively manually curated with links to source literature and other public resources on metabolism including enzyme and pathway databases. This cross-referencing facilitates the mapping and reconciliation of common reactions and compounds between distinct resources, which is a common first step in the reconstruction of genome scale metabolic networks and models.
Document type :
Journal articles
Complete list of metadata
https://hal.inria.fr/hal-00746861
Contributor : Marie-France Sagot Connect in order to contact the contributor
Submitted on : Monday, October 29, 2012 - 6:49:18 PM
Last modification on : Tuesday, July 20, 2021 - 5:20:04 PM
Contributor : Marie-France Sagot Connect in order to contact the contributor
Submitted on : Monday, October 29, 2012 - 6:49:18 PM
Last modification on : Tuesday, July 20, 2021 - 5:20:04 PM
Links full text
Identifiers
- HAL Id : hal-00746861, version 1
- DOI : 10.1093/nar/gkr1126
- PUBMED : 22135291
Citation
Rafael Alcântara, Kristian B Axelsen, Anne Morgat, Eugeni Belda, Elisabeth Coudert, et al.. Rhea--a manually curated resource of biochemical reactions.. Nucleic Acids Research, Oxford University Press, 2012, 40 (Database issue), pp.D754-60. ⟨10.1093/nar/gkr1126⟩. ⟨hal-00746861⟩
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