Numerical integration of a mathematical model of hematopoietic stem cell dynamics

Mostafa Adimy 1, * Oscar Angulo Fabien Crauste 2, 1, * Juan Carlos Lopez-Marcos
* Auteur correspondant
1 DRACULA - Multi-scale modelling of cell dynamics : application to hematopoiesis
CGMC - Centre de génétique moléculaire et cellulaire, Inria Grenoble - Rhône-Alpes, ICJ - Institut Camille Jordan [Villeurbanne], UCBL - Université Claude Bernard Lyon 1 : EA
Abstract : A mathematical model of hematopoiesis, describing the dynamics of stem cell population, is investigated. This model is represented by a system of two nonlinear age-structured partial differential equations, describing the dynamics of resting and proliferating hematopoietic stem cells. It differs from previous attempts to model the hematopoietic system dynamics by taking into account cell age-dependence of coefficients, that prevents a usual reduction of this system to an unstructured delay differential system. We prove the existence and uniqueness of a solution to our problem, and we investigate the existence of stationary solutions. A numerical scheme adapted to the problem is presented. We show the effectiveness of this numerical technique in the simulation of the dynamics of the solution. Numerical simulations show that long-period oscillations can be obtained in this model, corresponding to a destabilization of the system. These oscillations can be related to observations of some periodical hematological diseases (such as chronic myelogenous leukemia).
Type de document :
Article dans une revue
Computer and mathematics with applications, Elsevier, 2008, 56, pp.594-606. 〈10.1016/j.camwa.2008.01.003〉
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https://hal.inria.fr/hal-00750283
Contributeur : Fabien Crauste <>
Soumis le : vendredi 9 novembre 2012 - 13:42:39
Dernière modification le : mardi 16 janvier 2018 - 14:43:18

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Mostafa Adimy, Oscar Angulo, Fabien Crauste, Juan Carlos Lopez-Marcos. Numerical integration of a mathematical model of hematopoietic stem cell dynamics. Computer and mathematics with applications, Elsevier, 2008, 56, pp.594-606. 〈10.1016/j.camwa.2008.01.003〉. 〈hal-00750283〉

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