Using ontology-based annotation to profile disease research

Yi Liu 1 Adrien Coulet 1, 2 Paea Lependu 1 Nigam H Shah 1
2 ORPAILLEUR - Knowledge representation, reasonning
Inria Nancy - Grand Est, LORIA - NLPKD - Department of Natural Language Processing & Knowledge Discovery
Abstract : BACKGROUND: Profiling the allocation and trend of research activity is of interest to funding agencies, administrators, and researchers. However, the lack of a common classification system hinders the comprehensive and systematic profiling of research activities. This study introduces ontology-based annotation as a method to overcome this difficulty. Analyzing over a decade of funding data and publication data, the trends of disease research are profiled across topics, across institutions, and over time. RESULTS: This study introduces and explores the notions of research sponsorship and allocation and shows that leaders of research activity can be identified within specific disease areas of interest, such as those with high mortality or high sponsorship. The funding profiles of disease topics readily cluster themselves in agreement with the ontology hierarchy and closely mirror the funding agency priorities. Finally, four temporal trends are identified among research topics. CONCLUSIONS: This work utilizes disease ontology (DO)-based annotation to profile effectively the landscape of biomedical research activity. By using DO in this manner a use-case driven mechanism is also proposed to evaluate the utility of classification hierarchies.
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Article dans une revue
Journal of the American Medical Informatics Association, BMJ Publishing Group, 2012, 19 (e1), pp.e177-e186. 〈10.1136/amiajnl-2011-000631〉
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https://hal.inria.fr/hal-00752101
Contributeur : Adrien Coulet <>
Soumis le : mercredi 14 novembre 2012 - 18:13:26
Dernière modification le : jeudi 11 janvier 2018 - 06:25:24

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Yi Liu, Adrien Coulet, Paea Lependu, Nigam H Shah. Using ontology-based annotation to profile disease research. Journal of the American Medical Informatics Association, BMJ Publishing Group, 2012, 19 (e1), pp.e177-e186. 〈10.1136/amiajnl-2011-000631〉. 〈hal-00752101〉

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