System identification of the intrabrain tumoral uptake of multifunctional nanoparticles

Abstract : Recent developments on multifunctional nano-systems have opened new perspectives for tumor control by proposing new nano-actuators and nano-sensors in in vivo anti-cancer treatments. But the delivery control of these nano-agents into the cancer cells is one of the major factors that directly affect the efficiency of nanotherapies. In this study, we show that system identification methods (CONTSID Matlab toolbox), generally used in control engineering, can bring efficient solutions to help biologists to estimate crucial parameters of the nanoparticles pharmacokinetics from experimental data. The in vivo results presented herein clearly emphasize the relevance of these data-driven modeling approaches associated with magnetic resonance imaging.
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Conference papers
8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012, Aug 2012, Budapest, Hungary. pp.CDROM, 2012


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Submitted on : Tuesday, November 20, 2012 - 4:03:15 AM
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Jean-Baptiste Tylcz, Denise Bechet, Thierry Bastogne, Hugues Garnier, Muriel Barberi-Heyob. System identification of the intrabrain tumoral uptake of multifunctional nanoparticles. 8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012, Aug 2012, Budapest, Hungary. pp.CDROM, 2012. <hal-00753965>

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