A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin's lymphoma: investigation of the current protocol through theoretical modelling results.

Benjamin Ribba 1 K. Marron Z. Agur T. Alarcón P. K. Maini
1 NUMED - Numerical Medicine
Inria Grenoble - Rhône-Alpes, UMPA-ENSL - Unité de Mathématiques Pures et Appliquées
Abstract : Doxorubicin treatment outcomes for non-Hodgkin's lymphomas (NHL) are mathematically modelled and computationally analyzed. The NHL model includes a tumor structure incorporating mature and immature vessels, vascular structural adaptation and NHL cell-cycle kinetics in addition to Doxorubicin pharmacokinetics (PK) and pharmacodynamics (PD). Simulations provide qualitative estimations of the effect of Doxorubicin on high-grade (HG), intermediate-grade (IG) and low-grade (LG) NHL. Simulation results imply that if the interval between successive drug applications is prolonged beyond a certain point, treatment will be inefficient due to effects caused by heterogeneous blood flow in the system.
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Bulletin of Mathematical Biology, Springer Verlag, 2005, 67 (1), pp.79-99. 〈10.1016/j.bulm.2004.06.007〉
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Contributeur : Benjamin Ribba <>
Soumis le : jeudi 22 novembre 2012 - 19:35:05
Dernière modification le : mercredi 11 avril 2018 - 01:58:19

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Benjamin Ribba, K. Marron, Z. Agur, T. Alarcón, P. K. Maini. A mathematical model of Doxorubicin treatment efficacy for non-Hodgkin's lymphoma: investigation of the current protocol through theoretical modelling results.. Bulletin of Mathematical Biology, Springer Verlag, 2005, 67 (1), pp.79-99. 〈10.1016/j.bulm.2004.06.007〉. 〈hal-00756368〉

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