Skip to Main content Skip to Navigation
New interface
Journal articles

The Mimic Chain Reaction

Abstract : It is sometimes speculated that the equivalent of the polymerase chain reaction might be developed for identification of peptides, proteins or other molecules. In general, though, it is believed that there can be no way to amplify targets such as proteins. Natural amplification systems do, however, exist as in the case of certain autoinducer systems in bacteria. Here, we outline a possible, generic method, the mimic chain reaction, for obtaining peptides with 3-D structures that mimic the 3-D structure of their targets. These targets would include a variety of molecules, including proteins. There are therefore two categories of applications: the ability via amplification firstly to detect a known protein or other target at an extremely low concentration, and secondly to obtain a set of peptides that mimic the structure of an unknown target and that can be used to obtain a 'photofit'.
Complete list of metadata
Contributor : Patrick Amar Connect in order to contact the contributor
Submitted on : Wednesday, December 5, 2012 - 5:26:33 PM
Last modification on : Saturday, June 25, 2022 - 10:08:41 PM

Links full text



Vic Norris, Alain R Thierry, Patrick Amar, Barry I Holland, Franck Molina. The Mimic Chain Reaction. Journal of Molecular Microbiology and Biotechnology, 2012, 22 (5), pp.335-343. ⟨10.1159/000345328⟩. ⟨hal-00761608⟩



Record views