The Mimic Chain Reaction

Vic Norris 1, * Alain R Thierry 2 Patrick Amar 3, 4 Barry I Holland 5 Franck Molina 2
* Auteur correspondant
4 AMIB - Algorithms and Models for Integrative Biology
LIX - Laboratoire d'informatique de l'École polytechnique [Palaiseau], LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France, X - École polytechnique, CNRS - Centre National de la Recherche Scientifique : UMR8623
Abstract : It is sometimes speculated that the equivalent of the polymerase chain reaction might be developed for identification of peptides, proteins or other molecules. In general, though, it is believed that there can be no way to amplify targets such as proteins. Natural amplification systems do, however, exist as in the case of certain autoinducer systems in bacteria. Here, we outline a possible, generic method, the mimic chain reaction, for obtaining peptides with 3-D structures that mimic the 3-D structure of their targets. These targets would include a variety of molecules, including proteins. There are therefore two categories of applications: the ability via amplification firstly to detect a known protein or other target at an extremely low concentration, and secondly to obtain a set of peptides that mimic the structure of an unknown target and that can be used to obtain a 'photofit'.
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Article dans une revue
Journal of Molecular Microbiology and Biotechnology, Karger, 2012, 22 (5), pp.335-343. 〈10.1159/000345328〉
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Soumis le : mercredi 5 décembre 2012 - 17:26:33
Dernière modification le : mardi 5 juin 2018 - 10:14:24

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Vic Norris, Alain R Thierry, Patrick Amar, Barry I Holland, Franck Molina. The Mimic Chain Reaction. Journal of Molecular Microbiology and Biotechnology, Karger, 2012, 22 (5), pp.335-343. 〈10.1159/000345328〉. 〈hal-00761608〉

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