Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human

Nejib Zemzemi 1 Javier Saiz Rodriguez 2 Rodriguez Blanca 3
1 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, IHU-LIRYC
2 Universidad Politécnica de Valencia
3 Computing Science Laboratory - Oxford University
Abstract : Dofetilide is a class III drug whose use needs to be monitored due to the possible occurrence of Torsades de Pointes (TdP). The mechanisms are unclear but research suggests that both early-afterdepolarizations (EAD) and increased dispersion of action potential duration (APD) might be involved. Importantly, drug-induced TdP is more common in women, possibly due to higher L-type calcium current (ICaL) levels. Our goal is to use numerical simula- tion in order to investigate pro-arrhythmic mechanisms of dofetilide in human by characterizing its effects on APD, APD dispersion and EAD formation for varying doses and ICaL levels.
Type de document :
Communication dans un congrès
CinC 2012 - Computing in Cardiology, Sep 2012, Krakow, Poland. IEEE, Computing in Cardiology (CinC), 2012, pp.861-864, 2012
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Contributeur : Nejib Zemzemi <>
Soumis le : mercredi 12 décembre 2012 - 12:23:40
Dernière modification le : vendredi 13 avril 2018 - 19:56:04

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Nejib Zemzemi, Javier Saiz Rodriguez, Rodriguez Blanca. Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human. CinC 2012 - Computing in Cardiology, Sep 2012, Krakow, Poland. IEEE, Computing in Cardiology (CinC), 2012, pp.861-864, 2012. 〈hal-00764090〉

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