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Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human

Abstract : Dofetilide is a class III drug whose use needs to be monitored due to the possible occurrence of Torsades de Pointes (TdP). The mechanisms are unclear but research suggests that both early-afterdepolarizations (EAD) and increased dispersion of action potential duration (APD) might be involved. Importantly, drug-induced TdP is more common in women, possibly due to higher L-type calcium current (ICaL) levels. Our goal is to use numerical simula- tion in order to investigate pro-arrhythmic mechanisms of dofetilide in human by characterizing its effects on APD, APD dispersion and EAD formation for varying doses and ICaL levels.
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https://hal.inria.fr/hal-00764090
Contributor : Nejib Zemzemi Connect in order to contact the contributor
Submitted on : Wednesday, December 12, 2012 - 12:23:40 PM
Last modification on : Thursday, January 20, 2022 - 5:31:37 PM

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  • HAL Id : hal-00764090, version 1

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Nejib Zemzemi, Javier Saiz Rodriguez, Rodriguez Blanca. Role of L-type Calcium in Modulating Pro-Arrhythmic Effects of Dofetilide in Human. CinC 2012 - Computing in Cardiology, Sep 2012, Krakow, Poland. pp.861-864. ⟨hal-00764090⟩

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