H. Rehmann, A. Wittinghofer, and J. L. Bos, Capturing cyclic nucleotides in action: snapshots from crystallographic studies, Nature Reviews Molecular Cell Biology, vol.50, issue.1, pp.63-73, 2007.
DOI : 10.1038/nrm2082

H. Won, Y. Lee, S. Lee, L. , and B. , Structural overview on the allosteric activation of cyclic AMP receptor protein, BBA) - Proteins & Proteomics 1794, pp.1299-1308, 2009.
DOI : 10.1016/j.bbapap.2009.04.015

N. Popovych, S. Tzeng, M. Tonelli, R. H. Ebright, K. et al., Structural basis for cAMP-mediated allosteric control of the catabolite activator protein, Proceedings of the National Academy of Sciences, pp.6927-6932, 2009.
DOI : 10.1073/pnas.0900595106

C. Kim, C. Y. Cheng, S. A. Saldanha, T. , and S. S. , PKA-I Holoenzyme Structure Reveals a Mechanism for cAMP-Dependent Activation, Cell, vol.130, issue.6, pp.1032-1043, 2007.
DOI : 10.1016/j.cell.2007.07.018

M. Gloerich and J. L. Bos, Epac: Defining a New Mechanism for cAMP Action, Annual Review of Pharmacology and Toxicology, vol.50, issue.1, pp.355-375, 2010.
DOI : 10.1146/annurev.pharmtox.010909.105714

A. Cukkemane, R. Seifert, and U. B. Kaupp, Cooperative and uncooperative cyclic-nucleotide-gated ion channels, Trends in Biochemical Sciences, vol.36, issue.1, pp.55-64, 2011.
DOI : 10.1016/j.tibs.2010.07.004

URL : http://hdl.handle.net/11858/00-001M-0000-0028-61FD-0

G. M. Clayton, W. R. Silverman, L. Heginbotham, and J. H. Morais-cabral, Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel, Cell, vol.119, issue.5, pp.615-627, 2004.
DOI : 10.1016/j.cell.2004.10.030

S. L. Altieri, G. M. Clayton, W. R. Silverman, A. O. Olivares, E. M. De-la-cruz et al., Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain, Journal of Molecular Biology, vol.381, issue.3, pp.655-669, 2008.
DOI : 10.1016/j.jmb.2008.06.011

S. Schunke, M. Stoldt, K. Novak, U. B. Kaupp, and D. Willbold, Solution structure of the Mesorhizobium loti K1 channel cyclic nucleotide-binding domain in complex with cAMP, EMBO reports, vol.98, issue.7, pp.729-735, 2009.
DOI : 10.1021/bi00432a008

S. Schünke, M. Stoldt, J. Lecher, U. B. Kaupp, and D. Willbold, Structural insights into conformational changes of a cyclic nucleotide-binding domain in solution from Mesorhizobium loti K1 channel, Proceedings of the National Academy of Sciences, pp.6121-6126, 2011.
DOI : 10.1073/pnas.1015890108

P. Chiu, M. Pagel, J. Evans, H. Chou, X. Zeng et al., The Structure of the Prokaryotic Cyclic Nucleotide-Modulated Potassium Channel MloK1 at 16 ?? Resolution, Structure, vol.15, issue.9, pp.1053-1064, 2007.
DOI : 10.1016/j.str.2007.06.020

W. N. Zagotta, N. B. Olivier, K. D. Black, E. C. Young, R. Olson et al., Structural basis for modulation and agonist specificity of HCN pacemaker channels, Nature, vol.425, issue.6954, pp.200-205, 2003.
DOI : 10.1038/nature01922

J. W. Taraska, M. C. Puljung, N. B. Olivier, G. E. Flynn, and W. N. Zagotta, Mapping the structure and conformational movements of proteins with transition metal ion FRET, Nature Methods, vol.246, issue.7, pp.532-537, 2009.
DOI : 10.1093/protein/13.5.313

X. Xu, Z. V. Vysotskaya, Q. Liu, and L. Zhou, Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel, Journal of Biological Chemistry, vol.285, issue.47, pp.37082-37091, 2010.
DOI : 10.1074/jbc.M110.152033

H. Rehmann, B. Prakash, E. Wolf, A. Rueppel, J. De-rooij et al., Structure and regulation of the cAMP-binding domains of Epac2, Nature Structural Biology, vol.10, issue.1, pp.26-32, 2003.
DOI : 10.1038/nsb878

H. Rehmann, J. Das, P. Knipscheer, A. Wittinghofer, and J. L. Bos, Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state, Nature, vol.425, issue.7076, pp.625-628, 2006.
DOI : 10.1038/nature04468

J. C. Phillips, R. Braun, W. Wang, J. Gumbart, E. Tajkhorshid et al., Scalable molecular dynamics with NAMD, Journal of Computational Chemistry, vol.84, issue.16, pp.1781-1802, 2005.
DOI : 10.1002/jcc.20289

B. Hess, C. Kutzner, D. Van-der-spoel, and E. Lindahl, GROMACS 4:?? Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation, Journal of Chemical Theory and Computation, vol.4, issue.3, pp.435-447, 2008.
DOI : 10.1021/ct700301q

D. C. Bas, D. M. Rogers, and J. H. Jensen, Very fast prediction and rationalization of pKa values for protein-ligand complexes, Proteins: Structure, Function, and Bioinformatics, vol.25, issue.3, pp.765-783, 2008.
DOI : 10.1002/prot.22102

G. Bussi, D. Donadio, and M. Parrinello, Canonical sampling through velocity rescaling, The Journal of Chemical Physics, vol.126, issue.1, pp.14101-014101, 2007.
DOI : 10.1063/1.2408420

URL : http://arxiv.org/abs/0803.4060

M. Parrinello and A. Rahman, Polymorphic transitions in single crystals: A new molecular dynamics method, Journal of Applied Physics, vol.52, issue.12, pp.7182-7190, 1981.
DOI : 10.1063/1.328693

W. Humphrey, A. Dalke, and K. Schulten, VMD: Visual molecular dynamics, Journal of Molecular Graphics, vol.14, issue.1, pp.33-38, 1996.
DOI : 10.1016/0263-7855(96)00018-5

A. Kitao and N. Go, Investigating protein dynamics in collective coordinate space, Current Opinion in Structural Biology, vol.9, issue.2, pp.164-169, 1999.
DOI : 10.1016/S0959-440X(99)80023-2

E. Krissinel and K. Henrick, Inference of Macromolecular Assemblies from Crystalline State, Journal of Molecular Biology, vol.372, issue.3, pp.774-797, 2007.
DOI : 10.1016/j.jmb.2007.05.022

G. M. Clayton, S. Altieri, L. Heginbotham, V. M. Unger, and J. H. Morais-cabral, Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel, Proceedings of the National Academy of Sciences, pp.1511-1515, 2008.
DOI : 10.1073/pnas.0711533105

H. Ponstingl, K. Henrick, T. , and J. M. , Discriminating between homodimeric and monomeric proteins in the crystalline state, Proteins: Structure, Function, and Bioinformatics, vol.257, issue.1, pp.47-57, 2000.
DOI : 10.1002/1097-0134(20001001)41:1<47::AID-PROT80>3.0.CO;2-8

D. Van-valen, M. Haataja, and R. Phillips, Biochemistry on a Leash: The Roles of Tether Length and Geometry in Signal Integration Proteins, Biophysical Journal, vol.96, issue.4, pp.1275-1292, 2009.
DOI : 10.1016/j.bpj.2008.10.052

H. Rehmann, E. Arias-palomo, M. A. Hadders, F. Schwede, O. Llorca et al., Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B, Nature, vol.116, issue.7209, pp.124-127, 2008.
DOI : 10.1038/nature07187

A. Cukkemane, B. Grüter, K. Novak, T. Gensch, W. Bönigk et al., Subunits act independently in a cyclic nucleotide-activated K+ channel, EMBO reports, vol.55, issue.8, pp.749-755, 2007.
DOI : 10.1038/nature01922

G. E. Flynn, K. D. Black, L. D. Islas, B. Sankaran, and W. N. Zagotta, Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels, Structure, vol.15, issue.6, pp.671-682, 2007.
DOI : 10.1016/j.str.2007.04.008

C. M. Nimigean, T. Shane, and C. Miller, Channel, The Journal of General Physiology, vol.124, issue.3, pp.203-210, 2004.
DOI : 10.1093/emboj/17.2.353

URL : https://hal.archives-ouvertes.fr/inserm-01356847

N. Shi, S. Ye, A. Alam, L. Chen, and Y. Jiang, Atomic structure of a Na+- and K+-conducting channel, Nature, vol.114, issue.7083, pp.570-574, 2006.
DOI : 10.1038/nature04508

A. Alam and Y. Jiang, High-resolution structure of the open NaK channel, Nature Structural & Molecular Biology, vol.111, issue.1, pp.30-34, 2009.
DOI : 10.1038/nsmb.1531

. Fig, 3 Backbone fluctuations as a function of the residue number. (a) MlotiK1 CNBD homodimer