Graph Based Spatial Position Mapping of Low-grade Gliomas

Abstract : Low-grade gliomas (WHO grade II) are diffusively infiltra- tive brain tumors arising from glial cells. Spatial classification that is usually based on cerebral lobes lacks accuracy and is far from being able to provide some pattern or statistical interpretation of their appearance. In this paper, we propose a novel approach to understand and infer position of low-grade gliomas using a graphical model. The problem is formulated as a graph topology optimization problem. Graph nodes correspond to extracted tumors and graph connections to the spatial and content dependencies among them. The task of spatial position mapping is then expressed as an unsupervised clustering problem, where cluster centers correspond to centers with position appearance prior, and cluster samples to nodes with strong statistical dependencies on their position with respect to the cluster center. Promising results using leave-one-out cross-validation outperform conventional dimensionality reduction methods and seem to coincide with conclusions drawn in physiological studies regarding the expected tumor spatial distributions and interactions.
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Communication dans un congrès
MICCAI - 14th International Conference on Medical Image Computing and Computer-Assisted Intervention - 2011, Sep 2011, Toronto, Canada. Springer Berlin Heidelberg, pp.508-515, 2011, 〈10.1007/978-3-642-23629-7_62〉
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Sarah Parisot, Hugues Duffau, Stéphane Chemouny, Nikos Paragios. Graph Based Spatial Position Mapping of Low-grade Gliomas. MICCAI - 14th International Conference on Medical Image Computing and Computer-Assisted Intervention - 2011, Sep 2011, Toronto, Canada. Springer Berlin Heidelberg, pp.508-515, 2011, 〈10.1007/978-3-642-23629-7_62〉. 〈hal-00775865〉

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