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Journal Articles International Journal of Biotechnology and Bioengineering Year : 2011

Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA

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Abstract

Regulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established. Interaction features of studied miRNAs with 5'UTR, CDS and 3'UTR of mRNA of each gene were revealed. Functional regions of mRNA were shown to be significantly heterogenous according to the number of binding sites of miRNA and to the location density of these sites.
On a etabli une relation de regulation entre les miARN -intronique 686 et intergénique 784 et des ARNm de 51 genes. Des propriétés d'interaction des miARN avec les zones 5'UTR, CDS et 3'UTR des RNAm ont été mises en évidence. On a montré une hétérogénéité des régions fonctionnelles des ARNm par rapport au nombre de sites de fixation des miARM et à leur densité.
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hal-00779236 , version 1 (21-01-2013)

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Assel Issabekova, Olga Berillo, Vladimir Khailenko, Shara Atambayeva, Mireille Regnier, et al.. Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA. International Journal of Biotechnology and Bioengineering, 2011, 5 (11), pp.777-780. ⟨hal-00779236⟩
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