Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA

Assel Issabekova 1 Olga Berillo 1 Vladimir Khailenko 1 Shara Atambayeva 1 Mireille Regnier 2, 3, * Anatoliy Ivashchenko 1
* Corresponding author
2 AMIB - Algorithms and Models for Integrative Biology
LIX - Laboratoire d'informatique de l'École polytechnique [Palaiseau], LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France
Abstract : Regulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established. Interaction features of studied miRNAs with 5'UTR, CDS and 3'UTR of mRNA of each gene were revealed. Functional regions of mRNA were shown to be significantly heterogenous according to the number of binding sites of miRNA and to the location density of these sites.
Keywords : miRNA interaction
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  • HAL Id : hal-00779236, version 1
  • ARXIV : 1301.5093

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Assel Issabekova, Olga Berillo, Vladimir Khailenko, Shara Atambayeva, Mireille Regnier, et al.. Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA. World Academy of Science, Engineering and Technology, WASET, 2011, 59. ⟨hal-00779236⟩

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