General anaesthetics induce tonic inhibition and modulate the gain of neural populations : a modeling study

Axel Hutt 1, * Thomas Voegtlin 2
* Corresponding author
1 NEUROSYS - Analysis and modeling of neural systems by a system neuroscience approach
Inria Nancy - Grand Est, LORIA - AIS - Department of Complex Systems, Artificial Intelligence & Robotics
2 CORTEX - Neuromimetic intelligence
Inria Nancy - Grand Est, LORIA - AIS - Department of Complex Systems, Artificial Intelligence & Robotics
Abstract : Anaesthetic agents are known to affect extra-synaptic GABAergic receptors[1], which induce tonic inhibitory currents. Since these receptors are very sensitive to small concentrations of agents, they are supposed to play an important role in the underlying neural mechanism of general anaesthesia. Moreover anaesthetic agents modulate the encephalographic activity (EEG) of patients and hence show an effect on neural populations. To understand better the tonic inhibition effect in single neurons on neural populations modulating the EEG, the work considers a neural population in a steady-state and studies numerically and analytically the modulation of its population firing rate and the nonlinear gain with respect to different levels of tonic inhibition. We consider populations of both type-I and type-II neurons. The populations under study are heterogeneous involving distributions of firing thresholds and inhibitory conductances. The tonic inhibition introduces shunting action.
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Axel Hutt, Thomas Voegtlin. General anaesthetics induce tonic inhibition and modulate the gain of neural populations : a modeling study. CNS - Twenty First Annual Computational Neuroscience Meeting - 2012, Jun 2012, Decatur, United States. BioMed Central, 13 (Suppl 1), pp.P16, 2012, ⟨10.1186/1471-2202-13-S1-P16⟩. ⟨hal-00784398⟩

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