A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties.

Floriane Lignet 1 Vincent Calvez 1, 2 Emmanuel Grenier 1 Benjamin Ribba 1
1 NUMED - Numerical Medicine
Inria Grenoble - Rhône-Alpes, UMPA-ENSL - Unité de Mathématiques Pures et Appliquées
Abstract : The vascular endothelial growth factor (VEGF) is known as one of the main promoter of angiogenesis - the process of blood vessel formation. Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathways involved in the endothelial cells response to VEGF stimuli. The model, built on qualitative information from knowledge databases, is composed of 38 ordinary differential equations with 78 parameters and focuses on the signalling driving endothelial cell proliferation, migration and resistance to apoptosis. Following a VEGF stimulus, the model predicts an increase of proliferation and migration capability, and a decrease in the apoptosis activity. Model simulations and sensitivity analysis highlight the emergence of robustness and redundancy properties of the pathway. If further calibrated and validated, this model could serve as tool to analyse and formulate new hypothesis on th e VEGF signalling cascade and its role in cancer development and treatment.
Type de document :
Article dans une revue
Math Biosci Eng, American Institute of Mathematical Sciences, 2013, 10 (1), pp.167-84. 〈10.3934/mbe.2013.10.167〉
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https://hal.inria.fr/hal-00785874
Contributeur : Benjamin Ribba <>
Soumis le : jeudi 7 février 2013 - 11:17:01
Dernière modification le : mercredi 11 avril 2018 - 01:51:46

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Floriane Lignet, Vincent Calvez, Emmanuel Grenier, Benjamin Ribba. A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties.. Math Biosci Eng, American Institute of Mathematical Sciences, 2013, 10 (1), pp.167-84. 〈10.3934/mbe.2013.10.167〉. 〈hal-00785874〉

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