Electroclinical features of idiopathic generalized epilepsies in the elderly: a geriatric hospital-based study.

Abstract : PURPOSE: Idiopathic generalized epilepsies (IGE) are age-related epileptic syndromes mainly described in children and adolescence. Our aim is to describe their electroclinical features in the elderly. METHODS: Patients aged 70 years or more were prospectively selected in a geriatric EEG laboratory on the basis of rhythmic generalized spikes and waves discharges. Their clinical data were then examined to ascertain the syndromic diagnosis. RESULTS: Among 1181 geriatric patients referred for EEG over a 30-month period, IGE were identified in 10 cases. Eight patients began seizures in childhood or adulthood (3 childhood absence epilepsies, 2 juvenile/adult myoclonic epilepsies and 3 epilepsies with-generalized-tonic-clonic-seizures alone (EGTCS)) and 2 very late in life with EGTCS. The early-onset IGE cases had usually experienced a quiescent long period in adulthood before relapsing late in life. This relapse, mostly severe, consisted of absence status, myoclonic status or repeated generalized tonic clonic seizures and was often not-situation related. Absence status and myoclonic status were stopped by Clonazepam. The two late-onset IGE cases had familial history of epilepsy. Inappropriate antiepileptic drugs (AED) previously given in four patients with two worsenings were corrected. CONCLUSIONS: In this study, the non-negligible number of elderly cases observed over a short period of time suggests that IGE are frequent in the elderly but underestimated until recently. IGE may be lifelong with late severe exacerbations. A few very late-onset IGE cases exist. EEG remains useful in contributing to diagnose IGE and AED adjustment continues to be beneficial at extreme age.
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Seizure - European Journal of Epilepsy, Elsevier, 2011, 20 (4), pp.292-298. 〈10.1016/j.seizure.2010.12.013〉
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https://hal.inria.fr/hal-00795728
Contributeur : Olivier Colliot <>
Soumis le : jeudi 28 février 2013 - 18:34:15
Dernière modification le : mercredi 21 mars 2018 - 18:57:48

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Vi Huong Nguyen Michel, Claude Sebban, Sylvie Debray-Meignan, Zohra Ourabah, Marie-Claude Rousseau-Lavallard, et al.. Electroclinical features of idiopathic generalized epilepsies in the elderly: a geriatric hospital-based study.. Seizure - European Journal of Epilepsy, Elsevier, 2011, 20 (4), pp.292-298. 〈10.1016/j.seizure.2010.12.013〉. 〈hal-00795728〉

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