External globus pallidus stimulation modulates brain connectivity in Huntington's disease.

Abstract : Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.
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Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2011, 31 (1), pp.41-6. 〈10.1038/jcbfm.2010.186〉
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https://hal.inria.fr/hal-00795751
Contributeur : Olivier Colliot <>
Soumis le : jeudi 28 février 2013 - 19:21:16
Dernière modification le : vendredi 31 août 2018 - 08:47:54

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Noémie Ligot, Pierre Krystkowiak, Clémence Simonin, Serge Goldman, Philippe Peigneux, et al.. External globus pallidus stimulation modulates brain connectivity in Huntington's disease.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2011, 31 (1), pp.41-6. 〈10.1038/jcbfm.2010.186〉. 〈hal-00795751〉

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