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External globus pallidus stimulation modulates brain connectivity in Huntington's disease.

Abstract : Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.
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https://hal.inria.fr/hal-00795751
Contributor : Olivier Colliot <>
Submitted on : Thursday, February 28, 2013 - 7:21:16 PM
Last modification on : Thursday, March 11, 2021 - 1:26:01 PM

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Noémie Ligot, Pierre Krystkowiak, Clémence Simonin, Serge Goldman, Philippe Peigneux, et al.. External globus pallidus stimulation modulates brain connectivity in Huntington's disease.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2011, 31 (1), pp.41-6. ⟨10.1038/jcbfm.2010.186⟩. ⟨hal-00795751⟩

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