External globus pallidus stimulation modulates brain connectivity in Huntington's disease.

Noémie Ligot Pierre Krystkowiak 1 Clémence Simonin 2 Serge Goldman 3 Philippe Peigneux 4 John Van Naemen Michel Monclus Simon Frédéric Lacroix David Devos 5 Kathy Dujardin 6 Christine Delmaire 7 Eric Bardinet 8, 9 Arnaud Delval Marie Delliaux Luc Defebvre Jerome Yelnik 10, 8 Serge Blond 11 Alain Destée 12 Xavier De Tiège
1 Service de neurologie [Amiens]
2 Noyaux gris centraux
3 Hopital Erasme
4 Neuropsychology and Functional Neuroimaging Research Unit - UR2NF
5 IMRT, EA2683 - Department of Neurology et Pathologie du Mouvement
6 Neurology
7 Services de neuroradiologie [Lille]
8 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
9 CENIR - Centre de Neuro-Imagerie de Recherche
10 CIC AP-HP (pitie-Salpetriere)/inserm
11 JPArc - U837 Inserm - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer
12 Département de neurologie[Lille]
Abstract : Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.
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Article dans une revue
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2011, 31 (1), pp.41-6. 〈10.1038/jcbfm.2010.186〉
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https://hal.inria.fr/hal-00795751
Contributeur : Olivier Colliot <>
Soumis le : jeudi 28 février 2013 - 19:21:16
Dernière modification le : mardi 26 février 2019 - 10:12:37

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Noémie Ligot, Pierre Krystkowiak, Clémence Simonin, Serge Goldman, Philippe Peigneux, et al.. External globus pallidus stimulation modulates brain connectivity in Huntington's disease.. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2011, 31 (1), pp.41-6. 〈10.1038/jcbfm.2010.186〉. 〈hal-00795751〉

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