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Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?

Abstract : A common Single-Nucleotide Polymorphism in the Brain-Derived Neurotrophic Factor (BDNF) gene coding the Val66Met substitution in the pro-BDNF protein has been associated with a number of behavioural and neuroanatomical phenotypes; the latter include, for example, regional differences in volumes of the hippocampus and prefrontal grey matter. Here, we show that the observed regional differences may not stem from a localised effect of this gene. Our analysis of regional brain volume in a cohort of 331 adolescents indicates that the Val66Met substitution has a global effect on brain volume, and that the observed local differences are to be expected if brain allometry-the covariance pattern of regional brain volumes-is taken into account.
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https://hal.inria.fr/hal-00805413
Contributor : Olivier Colliot <>
Submitted on : Wednesday, March 27, 2013 - 6:51:55 PM
Last modification on : Tuesday, December 15, 2020 - 4:03:04 AM

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Roberto Toro, Marie Chupin, Line Garnero, Gabriel Leonard, Michel Perron, et al.. Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?. Brain Structure and Function, Springer Verlag, 2009, 213 (6), pp.501-9. ⟨10.1007/s00429-009-0203-y⟩. ⟨hal-00805413⟩

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