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Distinct striatal targets in treating obsessive-compulsive disorder and major depression.

Abstract : The ventral striatum, including the head of the caudate nucleus and the nucleus accumbens, is a putative target for deep brain stimulation (DBS) in the treatment of obsessive-compulsive disorder (OCD) and major depression (MD). However, the respective roles of these structures in the pathophysiology of OCD and MD remain to be clarified. To address this issue, DBS of the ventral striatum was tested in 2 patients with severely distressing and intractable forms of OCD and MD. Comparisons of clinical outcomes and anatomical data on electrode positioning showed that caudate nucleus stimulation preferentially alleviated OCD manifestations, whereas nucleus accumbens stimulation improved depressive symptoms. These findings suggest that the caudate nucleus and nucleus accumbens participate differently in the pathogenesis of both of these psychiatric conditions.
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https://hal.inria.fr/hal-00805419
Contributor : Olivier Colliot <>
Submitted on : Wednesday, March 27, 2013 - 7:03:12 PM
Last modification on : Thursday, December 10, 2020 - 3:37:25 AM

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Bruno Aouizerate, Emmanuel Cuny, Eric Bardinet, Jerome Yelnik, Corinne Martin-Guehl, et al.. Distinct striatal targets in treating obsessive-compulsive disorder and major depression.. Journal of Neurosurgery, American Association of Neurological Surgeons, 2009, 111 (4), pp.775-9. ⟨10.3171/2009.2.JNS0881⟩. ⟨hal-00805419⟩

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