Subthalamic nucleus stimulation in severe obsessive-compulsive disorder.
Luc Mallet
(1, 2)
,
Mircea Polosan
(3)
,
Nematollah Jaafari
(4)
,
Nicolas Baup
(5)
,
Marie-Laure Welter
(1, 2, 6)
,
Denys Fontaine
(7)
,
Sophie Tezenas Du Montcel
(6)
,
Jérôme Yelnik
(1, 2)
,
Isabelle Chéreau
(8)
,
Christophe Arbus
(9)
,
Sylvie Raoul
(10)
,
Bruno Aouizerate
,
Philippe Damier
(11)
,
Stephan Chabardès
(12)
,
Virginie Czernecki
(1, 6)
,
Claire Ardouin
(13)
,
Marie-Odile Krebs
(5)
,
Eric Bardinet
(1, 14, 15)
,
Patrick Chaynes
(16)
,
Pierre Burbaud
(17)
,
Philippe Cornu
(6)
,
Philippe Derost
,
Thierry Bougerol
(18, 19)
,
Benoit Bataille
,
Vianney Mattei
,
Didier Dormont
(15, 6)
,
Bertrand Devaux
(20, 21)
,
Marc Vérin
(22)
,
Jean-Luc Houeto
(23)
,
Pierre Pollak
(12, 24)
,
Alim-Louis Benabid
(25)
,
Yves Agid
(6)
,
Paul Krack
(12, 24)
,
Bruno Millet
(26, 27)
,
Antoine Pelissolo
(6)
,
Non Renseigné
1
CRICM -
Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
2 CIC AP-HP (pitie-Salpetriere)/inserm
3 Service de Psychiatrie
4 Immunologie antivirale systémique et cérébrale
5 Service de psychiatrie
6 CHU Pitié-Salpêtrière [AP-HP]
7 Service de Neurochirurgie
8 Service de psychiatrie
9 Service Anatomie et cytologie pathologiques [CHU Toulouse]
10 Service de physiologie
11 Clinique neurologique
12 GIN - Grenoble Institut des Neurosciences
13 UM des troubles du mouvement
14 CENIR - Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
15 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
16 Service Neurochirurgie [CHU Toulouse]
17 PPSC - Physiologie et physiopathologie de la signalisation cellulaire
18 Fondation FondaMental [Créteil]
19 Clinique Universitaire de Psychiatrie
20 Service Neurochirurgie
21 UPD5 - Université Paris Descartes - Paris 5
22 Service de Neurologie [Rennes] = Neurology [Rennes]
23 Service de neurologie [Poitiers]
24 Département de neurologie
25 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
26 Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
27 Service de psychiatrie
2 CIC AP-HP (pitie-Salpetriere)/inserm
3 Service de Psychiatrie
4 Immunologie antivirale systémique et cérébrale
5 Service de psychiatrie
6 CHU Pitié-Salpêtrière [AP-HP]
7 Service de Neurochirurgie
8 Service de psychiatrie
9 Service Anatomie et cytologie pathologiques [CHU Toulouse]
10 Service de physiologie
11 Clinique neurologique
12 GIN - Grenoble Institut des Neurosciences
13 UM des troubles du mouvement
14 CENIR - Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
15 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
16 Service Neurochirurgie [CHU Toulouse]
17 PPSC - Physiologie et physiopathologie de la signalisation cellulaire
18 Fondation FondaMental [Créteil]
19 Clinique Universitaire de Psychiatrie
20 Service Neurochirurgie
21 UPD5 - Université Paris Descartes - Paris 5
22 Service de Neurologie [Rennes] = Neurology [Rennes]
23 Service de neurologie [Poitiers]
24 Département de neurologie
25 CEA-LETI - Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
26 Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes]
27 Service de psychiatrie
Luc Mallet
- Fonction : Auteur
- PersonId : 758746
- ORCID : 0000-0001-8061-1167
- IdRef : 070449864
Sophie Tezenas Du Montcel
- Fonction : Auteur
- PersonId : 754144
- IdHAL : sophie-tezenas-du-montcel
- ORCID : 0000-0002-2866-4330
- IdRef : 256276617
Bruno Aouizerate
- Fonction : Auteur
- PersonId : 751079
- IdHAL : bruno-aouizerate
- ORCID : 0000-0002-7092-7747
- IdRef : 069471851
Philippe Damier
- Fonction : Auteur
- PersonId : 760632
- ORCID : 0000-0003-3869-0564
- IdRef : 099118076
Marie-Odile Krebs
- Fonction : Auteur
- PersonId : 757581
- ORCID : 0000-0002-4715-9890
- IdRef : 069691010
Eric Bardinet
- Fonction : Auteur
Philippe Derost
- Fonction : Auteur
Benoit Bataille
- Fonction : Auteur
Vianney Mattei
- Fonction : Auteur
Didier Dormont
- Fonction : Auteur
- PersonId : 1225581
- ORCID : 0000-0002-6080-1286
- IdRef : 075211238
Non Renseigné
- Fonction : Auteur
Résumé
BACKGROUND: Severe, refractory obsessive-compulsive disorder (OCD) is a disabling condition. Stimulation of the subthalamic nucleus, a procedure that is already validated for the treatment of movement disorders, has been proposed as a therapeutic option. METHODS: In this 10-month, crossover, double-blind, multicenter study assessing the efficacy and safety of stimulation of the subthalamic nucleus, we randomly assigned eight patients with highly refractory OCD to undergo active stimulation of the subthalamic nucleus followed by sham stimulation and eight to undergo sham stimulation followed by active stimulation. The primary outcome measure was the severity of OCD, as assessed by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), at the end of two 3-month periods. General psychopathologic findings, functioning, and tolerance were assessed with the use of standardized psychiatric scales, the Global Assessment of Functioning (GAF) scale, and neuropsychological tests. RESULTS: After active stimulation of the subthalamic nucleus, the Y-BOCS score (on a scale from 0 to 40, with lower scores indicating less severe symptoms) was significantly lower than the score after sham stimulation (mean [+/-SD], 19+/-8 vs. 28+/-7; P=0.01), and the GAF score (on a scale from 1 to 90, with higher scores indicating higher levels of functioning) was significantly higher (56+/-14 vs. 43+/-8, P=0.005). The ratings of neuropsychological measures, depression, and anxiety were not modified by stimulation. There were 15 serious adverse events overall, including 1 intracerebral hemorrhage and 2 infections; there were also 23 nonserious adverse events. CONCLUSIONS: These preliminary findings suggest that stimulation of the subthalamic nucleus may reduce the symptoms of severe forms of OCD but is associated with a substantial risk of serious adverse events. (ClinicalTrials.gov number, NCT00169377.)