Phase space reconstruction of an experimental model of cardiac field potential in normal and arrhythmic conditions

Abstract : Cardiac arrhythmias are one of the most important death causes in the world. Compared to the numerical models, the experimental ones provide a more realistic tool to study the mechanisms of cardiac arrhythmias. The in vitro culture of cardiac cells developed on the Multi-Electrodes Array (MEA) constitutes a suitable model in this context. The extracellular field potential (EFP) acquired from the MEA can be used to measure the electrophysiological parameters of action potential. In this article, the stability of this experimental model is investigated using the phase space reconstruction in normal and in arrhythmia conditions. The results show that the embedding dimension of signal EFP changed slightly in both cases (normal conditions and arrhythmia). The parameter time lag $\tau$ in the normal conditions is lower than in the arrhythmia. The shape of attractors remains similar but disturbed in case of arrhythmia compared to the normal conditions.
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https://hal.inria.fr/hal-00812198
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Binbin Xu, Sabir Jacquir, Gabriel Laurent, Jean-Marie Bilbault, Stéphane Binczak. Phase space reconstruction of an experimental model of cardiac field potential in normal and arrhythmic conditions. EMBC 2013 - 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Jul 2013, Osaka, Japan. pp.3274 - 3277, ⟨10.1109/EMBC.2013.6610240⟩. ⟨hal-00812198⟩

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