Toward a Comprehensive Framework for the Spatiotemporal Statistical Analysis of Longitudinal Shape Data

Abstract : This paper proposes an original approach for the statistical analysis of longitudinal shape data. The proposed method allows the characterization of typical growth patterns and subject-specific shape changes in repeated timeseries observations of several subjects. This can be seen as the extension of usual longitudinal statistics of scalar measurements to high-dimensional shape or image data. The method is based on the estimation of continuous subject-specific growth trajectories and the comparison of such temporal shape changes across subjects. Differences between growth trajectories are decomposed into morphological deformations, which account for shape changes independent of the time, and time warps, which account for different rates of shape changes over time. Given a longitudinal shape data set, we estimate a mean growth scenario representative of the population, and the variations of this scenario both in terms of shape changes and in terms of change in growth speed. Then, intrinsic statistics are derived in the space of spatiotemporal deformations, which characterize the typical variations in shape and in growth speed within the studied population. They can be used to detect systematic developmental delays across subjects. In the context of neuroscience, we apply this method to analyze the differences in the growth of the hippocampus in children diagnosed with autism, developmental delays and in controls. Result suggest that group differences may be better characterized by a different speed of maturation rather than shape differences at a given age. In the context of anthropology, we assess the differences in the typical growth of the endocranium between chimpanzees and bonobos. We take advantage of this study to show the robustness of the method with respect to change of parameters and perturbation of the age estimates.
Complete list of metadatas

Cited literature [38 references]  Display  Hide  Download

https://hal.inria.fr/hal-00813825
Contributor : Stanley Durrleman <>
Submitted on : Tuesday, April 30, 2013 - 12:55:19 PM
Last modification on : Thursday, October 31, 2019 - 1:18:09 AM
Long-term archiving on : Monday, April 3, 2017 - 5:54:17 AM

File

Durrleman_IJCV_2012_Longitudin...
Files produced by the author(s)

Identifiers

Citation

Stanley Durrleman, Xavier Pennec, Alain Trouvé, José Braga, Guido Gerig, et al.. Toward a Comprehensive Framework for the Spatiotemporal Statistical Analysis of Longitudinal Shape Data. International Journal of Computer Vision, Springer Verlag, 2013, 103 (1), pp.22-59. ⟨10.1007/s11263-012-0592-x⟩. ⟨hal-00813825⟩

Share

Metrics

Record views

1174

Files downloads

436