Analysis of longitudinal shape variability via subject specific growth modeling.

James Fishbaugh 1 Marcel Prastawa 1 Stanley Durrleman 2, 3 Joseph Piven 4 Guido Gerig 1
1 SCI Institute - Scientific Computing and Imaging Institute
2 ASCLEPIOS - Analysis and Simulation of Biomedical Images
CRISAM - Inria Sophia Antipolis - Méditerranée
3 NEMESIS-CRICM - Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière
CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
4 Carolina Institute for Developmental Disabilities
Abstract : Statistical analysis of longitudinal imaging data is crucial for understanding normal anatomical development as well as disease progression. This fundamental task is challenging due to the difficulty in modeling longitudinal changes, such as growth, and comparing changes across different populations. We propose a new approach for analyzing shape variability over time, and for quantifying spatiotemporal population differences. Our approach estimates 4D anatomical growth models for a reference population (an average model) and for individuals in different groups. We define a reference 4D space for our analysis as the average population model and measure shape variability through diffeomorphisms that map the reference to the individuals. Conducting our analysis on this 4D space enables straightforward statistical analysis of deformations as they are parameterized by momenta vectors that are located at homologous locations in space and time. We evaluate our method on a synthetic shape database and clinical data from a study that seeks to quantify brain growth differences in infants at risk for autism.
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Communication dans un congrès
Nicholas Ayache and Hervé Delingette and Polina Golland and Kensaku Mori. MICCAI - Medical Image Computing And Computer Assisted Intervention, Oct 2012, Nice, France. Springer, 7510 (Pt 1), pp.731-738, 2012, Lecture Notes in Computer Science (LNCS). 〈10.1007/978-3-642-33415-3_90〉
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https://hal.inria.fr/hal-00818412
Contributeur : Stanley Durrleman <>
Soumis le : mardi 27 août 2013 - 12:26:58
Dernière modification le : jeudi 17 janvier 2019 - 13:48:03

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James Fishbaugh, Marcel Prastawa, Stanley Durrleman, Joseph Piven, Guido Gerig. Analysis of longitudinal shape variability via subject specific growth modeling.. Nicholas Ayache and Hervé Delingette and Polina Golland and Kensaku Mori. MICCAI - Medical Image Computing And Computer Assisted Intervention, Oct 2012, Nice, France. Springer, 7510 (Pt 1), pp.731-738, 2012, Lecture Notes in Computer Science (LNCS). 〈10.1007/978-3-642-33415-3_90〉. 〈hal-00818412〉

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